Clinically Significant Drug Interactions - March 15, 2000 - American Academy of Family Physicians: "Tramadol
Tramadol (Ultram) is a centrally acting analgesic with two modes of action: weak binding to the µ-opiate receptor and inhibition of norepinephrine and serotonin reuptake. Reports of serotonin syndrome in association with tramadol and SSRI coadministration appear in the literature.27 Because depression and chronic pain syndromes frequently coexist, physicians are likely to encounter situations in which this combination is used"
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