One theory is that the relatively short half life of paroxetine and venlafaxinemake these two drugs more problematic. This leads to a withdrawal strategythat advocates switching from paroxetine or other drugs to fluoxetine.The second is that paroxetine and venlafaxine are relatively more potentserotonin reuptake inhibitors and this theory leads to a switch to less potentserotonin reuptake inhibitors such as citalopram
Seroxat/paroxetine half life = 21 to 26 hours,
Efexor/venlafaxine half life = 5 (5 to 11) hours
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