what Fiddaman doesn't tell you - Venlafaxine half life considerably shorter than Seroxat

SEROXAT SUFFERERS - STAND UP AND BE COUNTED:


"Compared with other SSRIs, paroxetine has a short half-life, no active metabolite, a greater anticholinergic effect and greater potency in blocking serotonin reuptake, which could be seen as contributing factors.3,"



Antidepressant Half Life Information

source -http://www.clinical-depression.co.uk/Understanding_Depression/half_life.htm
Sep-01

drug generic name company type max mg/day Half life, hrs

Anafranil clomipramine Novartis TCAD 250 21(19-37)
Asendis amoxapine Wyeth TCAD 300 no info
Cipramil Lundbeck SSRI 60 36 (28 - 42)
Elderly patients may metabolise more slowly and need lower dose
Edronax Pharmacia SNRI 12 8
Efexor venlafaxine Wyeth SSNRI 375 5 (5 to 11)
" XL Wyeth SSNRI 225 20 to 22
Faverin Solvay SSRI 300 21
Lentizol amitriptyline hyd. Pfizer 200 15 (10 - 28)
Nortriptyline, the most important metabolite, has a half-life of 36 hours (18-60 hours).
It has a polymorphically controlled metabolism (debrisoquine metabolism). In subjects
with a slow metabolism (in Switzerland about 9% of the population) high therapeutic
doses can lead to toxic plasma levels very quickly.
Lustral, sertraline Pfizer SSRI 200 26 (22 to 33)
Prothiaden dothiepin hyd. Knoll TCAD 150 19 to 33
Prozac fluoxetine Dista SSRI 7 to 9 DAYS
Approx. 7% of people have difficulty metabolising fluoxetine and it then increases rapidly
Seroxat paroxetine GSK SSRI 50 21 to 26 Sinequan doxepin Pfizer TCAD 100x3 p.d. 28 to 52
Surmontil trimipramine Futuna TCAD 300 24
Tofranil imipramine Novartis TCAD 200 19
Elderly shown to have slower metabolism giving half life of 28 hours.
Young me shown to have higher metabolism giving half life of 16 hours.
Triptafen phenothiazine Goldshield TCAD 4 tabs daily 30
Zispin mirtazapine Organon N&S enhancer 45 20 to 40