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Friday, 3 February 2012

SEROXAT - Abnormal Brain Structure Implicated in Stimulant Drug Addiction - FIDDAMAN counterpoint blog

Science 3 February 2012:

Vol. 335 no. 6068 pp. 601-604

DOI: 10.1126/science.1214463


Abnormal Brain Structure Implicated in Stimulant Drug Addiction

Karen D. Ersche1,*, P. Simon Jones1, Guy B. Williams1,2, Abigail J Turton1, Trevor W. Robbins1, Edward T. Bullmore1,3,4

+ Author Affiliations

1Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology and Department of Psychiatry, University of Cambridge, Cambridge, CB2 3EB and CB2 0SZ, UK.

2Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

3Clinical Unit Cambridge, GlaxoSmithKline, Addenbrooke’s Centre for Clinical Investigations, Cambridge CB2 2GG, UK.

4Cambridgeshire and Peterborough Foundation, National Health Service Trust, Cambridge CB21 5EF, UK.

↵*To whom correspondence should be addressed. E-mail:


Addiction to drugs is a major contemporary public health issue, characterized by maladaptive behavior to obtain and consume an increasing amount of drugs at the expense of the individual’s health and social and personal life. We discovered abnormalities in fronto-striatal brain systems implicated in self-control in both stimulant-dependent individuals and their biological siblings who have no history of chronic drug abuse; these findings support the idea of an underlying neurocognitive endophenotype for stimulant drug addiction.

Received for publication 26 September 2011.

Accepted for publication 29 November 2011.

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