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Sunday, 13 May 2012

Seroxat may cause suicidal thinking at EARLY stage of treatment - NHS admit see FIDDAMAN blog

Seroxat (Seroxat 20mg tablets)

Information specific to: Seroxat 20mg tablets when used in Anxiety.

Seroxat (Sair-rox-at) is a medicine which is used in a number of conditions - an example is treatment of anxiety. Seroxat contains paroxetine hydrochloride. It is supplied by GlaxoSmithKline UK.

The information in this Medicine Guide for seroxat varies according to the condition being treated and the particular preparation used.

Your medicine

Seroxat is used to treat a variety of mental health problems. It is thought that Seroxat increases the activity and levels of certain chemicals in the brain. This can improve symptoms such as depression and anxiety.

Some people who take Seroxat may find that it intensifies depression and suicidal feelings in the early stages of treatment. These people have an increased risk of self-harm or suicide in the early stages of taking Seroxat. As Seroxat starts to work these risks decrease.

If you are taking Seroxat, or you care for someone who is taking Seroxat, you need to look out for changes in behaviour that could be linked to self-harm or suicide.

If you notice any of these changes or are worried about how Seroxat is affecting you or someone you care for, you should contact your prescriber, a mental health professional or NHS Direct as soon as possible.

It is important that you discuss with your prescriber how long it will take before you can expect to feel any benefits from taking Seroxat.

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Seroxat is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

•are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine

•are elderly

•are having electroconvulsive therapy

•are prone to bleeding or have had bleeding problems

•are self-harming or have self-harmed in the past

•are taking monoamine oxidase inhibitors or have taken them within the last two weeks

•have a movement disorder

•have diabetes

•have epilepsy

•have had glaucoma

•have heart problems

•have kidney problems

•have liver problems

•have narrow angle glaucoma

•have or have had mania

•have or have had suicidal thoughts or if you have attempted suicide

•have risk factors for low levels of sodium in your blood such as livercirrhosis or are taking medicines that reduce sodium levels in the blood

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone under 18 years of age.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

•to check that this medicine is not having any undesired effects

Over time it is possible that Seroxat can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Seroxat has become unsuitable, it is important that the prescriber is contacted immediately.


Alcohol can interact with certain medicines.

It is best to avoid drinking alcohol while you are taking this medicine.


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Seroxat:

•there are no specific foods that you must exclude from your diet when taking Seroxat

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Seroxat:

•this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Seroxat:

•you should only take this medicine during pregnancy if your doctor thinks that you need it

•if you are taking Seroxat and are planning to have a baby you must contact your prescriber

•if you become pregnant, or think you have become pregnant while taking Seroxat, you must contact your prescriber

•if you take this medicine during the late stages of pregnancy your baby may have some problems after birth

•this medicine may decrease fertility in men

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Seroxat, then you should discuss whether there is an alternative medicine that you could take during pregnancy.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Seroxat:

•you should only take this medicine while breast-feeding if your doctor thinks you need it

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. You should only breast-feed your baby while taking this medicine on the advice of your doctor or midwife.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Seroxat:






























The following types of medicine may interact with Seroxat:



•atypical antipsychotics

•COX-2 inhibitors

•cytochrome P450 enzyme inducers

•cytochrome P450 enzyme inhibitors

•medicines that affect platelet function or increase risk of bleeding

•monoamine oxidase inhibitors

•non-steroidal anti-inflammatories

•oral anticoagulants




•serotonin precursors

•tricyclic antidepressants


If you are taking Seroxat and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins.

Make sure you tell your prescriber the names of all the complementary preparations and vitamins that you are taking or are planning to take.

Your prescriber can then decide whether it is appropriate for you to take combinations that are known to interact.

In the case of Seroxat:

•this medicineinteracts with St. John's Wort

If you have been prescribed Seroxat you should only take something on the above list on the specific advice of your prescriber or pharmacist.

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