The power of the press - alt.rock-n-roll.acdc Google Groups: "BOB FIDDAMAN View profile Translated (View Original)
More options Jun 4 2001, 1:43 pm
Newsgroups: alt.rock-n-roll.acdcFrom: 'BOB FIDDAMAN' Date: Mon, 4 Jun 2001 13:38:19 +0100Local: Mon, Jun 4 2001 1:38 pm Subject: The power of the pressReply to author Forward Print Individual message Show original Remove Report this message Find messages by this author
Was emailed by Rover this morning. They want me to go in tomorrow to discuss
a potential job vacancy.
I wonder where they magicked(sp) that one from.
--
And Remember......
KEEP IT STIFF
BOB FIDDAMAN UK
Remove NOSPAM to reply personally.
http://trak.to/ACDC (NEWSGROUP SITE)
http://2go.it/corinthians/ (CORINTHIANS UNDER 13'S FC)
http://bobfiddaman.123go.cx/ (MY POETRY SITE) Winner of the Poetry Splash
Award"
Tuesday, 31 March 2009
I was hoping to do the States or even Canada
Welcome to my rant - alt.rock-n-roll.acdc Google Groups: "I was hoping to do the States or even Canada. I can't really go into too
much detail as to why I now cannot because Chinese Chunky Bollocks will
cease the opportunity to use it against me. Howvwer, if you want to know the
details email me.
--
and remember...
KEEP IT STIFF
Ballbreaker 375
Bob Fiddaman
Birmingham UK
ballbreaker...@breathemail.net
http://members.xoom.com/_XMCM/bobfiddaman/index.html (AC/DC Homepage)
http://www.bfiddaman.fsnet.co.uk/humour%20website/humour.htm (Poetry)
http://members.xoom.com/bobfiddaman/index2.html (2nd Poetry page)"
much detail as to why I now cannot because Chinese Chunky Bollocks will
cease the opportunity to use it against me. Howvwer, if you want to know the
details email me.
--
and remember...
KEEP IT STIFF
Ballbreaker 375
Bob Fiddaman
Birmingham UK
ballbreaker...@breathemail.net
http://members.xoom.com/_XMCM/bobfiddaman/index.html (AC/DC Homepage)
http://www.bfiddaman.fsnet.co.uk/humour%20website/humour.htm (Poetry)
http://members.xoom.com/bobfiddaman/index2.html (2nd Poetry page)"
shrieking whiney fishwife. If you put half the effort in your work as you do in this NG, you would be the fucking CEO of Rover
Overdose of Bob - alt.rock-n-roll.acdc Google Groups: "You know, Bob, you have really gone full circle in this NG. You first
came in here spouting your poetry and you got all pissy when no one
liked it. Then there came the flame wars, then you started being a
contributor of the NG and you seemed to be respected by the others.
You reached a plateau and when your job announcement was met with
responses similar to your poetry, you have basically comeback to what
you were from the beginning. A shrieking whiney fishwife. If you put
half the effort in your work as you do in this NG, you would be the
fucking CEO of Rover"
came in here spouting your poetry and you got all pissy when no one
liked it. Then there came the flame wars, then you started being a
contributor of the NG and you seemed to be respected by the others.
You reached a plateau and when your job announcement was met with
responses similar to your poetry, you have basically comeback to what
you were from the beginning. A shrieking whiney fishwife. If you put
half the effort in your work as you do in this NG, you would be the
fucking CEO of Rover"
Bob Fiddaman has no difficulty "decorating"
BOB FIDDAMAN, anyone else read - alt.rock-n-roll.acdc Google Groups: "Cheers Jim,
Sorry I never got back to you personally only I've been decorating!!!!!!
Whoever invented decorating wants fucking!!!!!!
I'll mail you my addy soon.
--
and remember...
KEEP IT STIFF
Ballbreaker 375
Bob Fiddaman
Birmingham UK
http://www.fortunecity.com/tinpan/rockroll/1217/index.htm (AC/DC Newsgroup
Member Pages)
http://wwp.icq.com/97656404 (ICQ)"
Sorry I never got back to you personally only I've been decorating!!!!!!
Whoever invented decorating wants fucking!!!!!!
I'll mail you my addy soon.
--
and remember...
KEEP IT STIFF
Ballbreaker 375
Bob Fiddaman
Birmingham UK
http://www.fortunecity.com/tinpan/rockroll/1217/index.htm (AC/DC Newsgroup
Member Pages)
http://wwp.icq.com/97656404 (ICQ)"
whilst Fiddaman Scott & Venn hogged the media - Florida was giving antipsychotics to infants under 1
SSRI DISCUSSION FORUM: 23 infants aged under 1 given antipsychotics in Florida in 2007: "State figures show there was a 40 percent drop in the number of preschoolers receiving these drugs. Use was pared back at every age level and eliminated for infants under age 1, for whom there were 23 such prescriptions in 2007.
The number of kids under 6 prescribed more than one of the drugs also dropped, from 73 to 28.
http://www.tampabay.com/news/health/article987612.ece"
The number of kids under 6 prescribed more than one of the drugs also dropped, from 73 to 28.
http://www.tampabay.com/news/health/article987612.ece"
Monday, 30 March 2009
Mark Harvey on Seroxat said "They can preserve their market - they can preserve their drugs where they are doing some good"
Week in week out video Dr David Healy & others
http://web.archive.org/web/20061018054241/www.bbc.co.uk/wales/weekinweekoutGiving advice to GSKThey have a chance to do themselves some goodThey can preserve their market - they can preserve their drugs where they are doing some goodaddress peoples problems I'm an optomist & hope that can happen
Seroxat is a "brilliant" drug which gives people their lives back, according to Panorama viewer
Seroxat gave me my life back
Dawn Daly says the drug worked for her
Dawn Daly says the drug worked for her
http://news.bbc.co.uk/1/hi/programmes/panorama/3012473.stm
Seroxat is a "brilliant" drug which gives people their lives back, according to one Panorama viewer.
Dawn Daly wrote to Panorama after the first Seroxat programme because she was annoyed at what she saw as the negative portrayal of the anti-depressant.
She was put on Seroxat after suffering from panic attacks and says the experience has done her nothing but good.
Dawn added that as she watched the first programme she thought: "What I watched on the programme didn't relate at all to my experiences having taken Seroxat. It was almost as if they were taking a completely different drug to what I take."
Praise
It has helped me tremendously
Dawn DalyShe said that taking the drug had a marked effect on her condition, adding: "I had more enthusiasm to do my job, to carry out day to day tasks.
"I had more confidence in dealing with things that previously stressed me out. And basically it felt as if I'd been given my life back."
And despite being on the drug for five years, Dawn says she has never experienced any suicidal thoughts and in fact has nothing but praise for Seroxat.
"I know several people that are taking Seroxat - family and friends, and it's greatly improved their lives," she said.
"If I were to give a message to Glaxo SmithKline it would be that it's a brilliant drug. It has helped me tremendously, " added Dawn.
"But you need to look at the side effects - if there's anything that can be done for withdrawal, where people don't need to be on it for a long time."
Seroxat campaigner Bob Fiddaman admits - "They [Seroxat] worked for me"
Hi Nathan,I can agree with you to a certain extent regarding whether they work. They [Seroxat] worked for me… if masking the illness and losing all empathy is working.http://209.85.229.132/search?q=cache:62zY663SNEcJ:www.pharmalot.com/2008/06/grassley-probes-paxil-suicide-risks/+mark+harvey+fiddaman&hl=en&ct=clnk&cd=7&gl=uk
Seroxat campaigner Derek Scott admits - "Seroxat does help"
http://web.archive.org/web/20030110084126/forum.onecenter.com/cgi-bin/forum/forum.cgi?c=msg&fid=seroxat&mid=88Name: Derek Subject: Re: Seroxat Tue, Dec 10 2002 at 12:18 pm [ Email Msg Invite ] Message:
all antidepressants cause some form of withdrawal, saying this though Seroxat is the #1 drug in the UK in terms of causing severe withdrawal symptoms, and is also #1 on the World Health Organization hit list of drugs that cause withdrawal, and therefore dependence. Seroxat does help, just be sure you know what you are letting yourself in for in the long term. Derek
all antidepressants cause some form of withdrawal, saying this though Seroxat is the #1 drug in the UK in terms of causing severe withdrawal symptoms, and is also #1 on the World Health Organization hit list of drugs that cause withdrawal, and therefore dependence. Seroxat does help, just be sure you know what you are letting yourself in for in the long term. Derek
Sunday, 29 March 2009
"A spokeswoman for the Seroxat Users Group said: 'We acknowledge that treatment with Seroxat is beneficial to many patients."
"A spokeswoman for the Seroxat Users Group said: 'We acknowledge that treatment with Seroxat is beneficial to many patients."
'Seroxat saved my life'
Emma Wallace says the drug worked for her
The government's Committee on the Safety of Medicines has launched an inquiry into anti-depressant drugs such as Seroxat and Prozac following claims by patients that they had become hooked on the pills, or felt suicidal after taking them.
Health Minister Hazel Blears revealed last week that between 2000 and 2002, the Department of Health's Yellow Card scheme had received eight reports of suicides and more than 1,000 reports of adverse reactions among patients who had taken Seroxat.
However, the drug has been taken successfully by many thousands of people world-wide. BBC News Online's Jane Elliott spoke to one woman who believes the drug saved her life.
Emma Wallace is a bubbly, vivacious cellist.
She is newly-wed and has a lovely home and a job she adores with the London Symphony Orchestra.
To an impartial observer she looks to have the perfect life.
But scratch the surface and the hidden problems soon become apparent.
Depressed
For until a year ago Emma was a chronic self-harmer. She needed hospital treatment three times after cutting herself deeply and her body still bears the scars.
She has contemplated suicide and told her family she was ready to die.
I have hideous scars where I used to cut myself with knives and razor blades.
Emma Wallace
Emma, 38, suffers from chronic insomnia and has spent most of life unable to sleep.
She is a depressive after being badly abused by a babysitter as a child.
But a year ago she found her salvation - the controversial antidepressant pill Seroxat. She and now wants to speak out because she feels that drug has received such a bad press that some people are not taking it.
The drug has been linked to withdrawal problems, suicide and self-harm.
But to Emma the drug has been a godsend.
"I was very low. I could not answer the telephone to anyone I could not even talk to family.
"I just had no confidence.
"I used to self harm. I have hideous scars where I used to cut myself with knives and razor blades. I started doing this when I was 11 and it continued until I was 28.
Sleep
But then Emma was referred to the sleep disorders centre at St Thomas's Hospital, in South London.
Doctors established that she had very low levels of serotonin in her brain, the chemical that enhances mood and promotes sleep.
She was prescribed Seroxat to boost the serotonin levels and says she noticed a mood change immediately.
"Within three weeks of taking it I was feeling like a different person. I suddenly wanted to get out of bed.
"When I was playing the cello I used to think everyone was looking at me and waiting for me to make a mistake, but now I sit there and think that I am good at what I do.
"When the doctor asked me how I had found the drug I told him that for my whole life I had been living in a prison and that he had opened the gates.
"Nobody understood what it was like they couldn't see behind the great glittering career, the wonderful husband and the brilliant house."
Life
She said that at first she had been reluctant to take the anti-depressants because of the stigma attached, but said that she was glad she had persevered.
"I feel people are missing the chance to change their lives. I was in a pretty bad way a couple of years ago and it has changed my life.
"Since I have taken Seroxat I have realised that I am this bubbly person that everybody loves. I have this chemical imbalance.
"I have always had it and I will always take Seroxat."
But others fear the influence of the drug.
A spokeswoman for the Seroxat Users Group said: "We acknowledge that treatment with Seroxat is beneficial to many patients.
"Unfortunately there are an unacceptable number of patients who are suffering because they have taken Seroxat, finding themselves addicted to the drug and not infrequently overcome by suicidal ideation, resulting in the loss of life.
"The Seroxat Users Group is deeply concerned about the safety of Seroxat and is calling on the Medicines and Healthcare products Regulatory Agency (MHRA) to withdraw any new prescriptions of Seroxat until the review into its safety is complete.
"World Health Organisation statistics show that Seroxat has more reports of withdrawal difficulties and adverse reactions than any other prescribed drug, with twice as many reports as the next highest drug. The benzodiazepine Valium ranks 13th.
"There is an urgent need for independent research into the long-term effects of Seroxat, special facilities equipped to assist patient's during withdrawal, and amendment of patient and prescriber information to reflect the dangers of treatment with Seroxat."
Maker's response
A spokesperson for GlaxoSmithKline, which makes the drug, said: "Depression is a potentially deadly disease and Seroxat is an effective treatment that since launch has helped tens of millions of patients worldwide lead fuller and more productive lives.
"The majority of people do not get side effects on either taking Seroxat or on stopping.
"But some people do and we have been advising patients and doctors on what to expect, when taking or stopping treatment for many years."
Health Minister Hazel Blears revealed last week that between 2000 and 2002, the Department of Health's Yellow Card scheme had received eight reports of suicides and more than 1,000 reports of adverse reactions among patients who had taken Seroxat.
However, the drug has been taken successfully by many thousands of people world-wide. BBC News Online's Jane Elliott spoke to one woman who believes the drug saved her life.
Emma Wallace is a bubbly, vivacious cellist.
She is newly-wed and has a lovely home and a job she adores with the London Symphony Orchestra.
To an impartial observer she looks to have the perfect life.
But scratch the surface and the hidden problems soon become apparent.
Depressed
For until a year ago Emma was a chronic self-harmer. She needed hospital treatment three times after cutting herself deeply and her body still bears the scars.
She has contemplated suicide and told her family she was ready to die.
I have hideous scars where I used to cut myself with knives and razor blades.
Emma Wallace
Emma, 38, suffers from chronic insomnia and has spent most of life unable to sleep.
She is a depressive after being badly abused by a babysitter as a child.
But a year ago she found her salvation - the controversial antidepressant pill Seroxat. She and now wants to speak out because she feels that drug has received such a bad press that some people are not taking it.
The drug has been linked to withdrawal problems, suicide and self-harm.
But to Emma the drug has been a godsend.
"I was very low. I could not answer the telephone to anyone I could not even talk to family.
"I just had no confidence.
"I used to self harm. I have hideous scars where I used to cut myself with knives and razor blades. I started doing this when I was 11 and it continued until I was 28.
Sleep
But then Emma was referred to the sleep disorders centre at St Thomas's Hospital, in South London.
Doctors established that she had very low levels of serotonin in her brain, the chemical that enhances mood and promotes sleep.
She was prescribed Seroxat to boost the serotonin levels and says she noticed a mood change immediately.
"Within three weeks of taking it I was feeling like a different person. I suddenly wanted to get out of bed.
"When I was playing the cello I used to think everyone was looking at me and waiting for me to make a mistake, but now I sit there and think that I am good at what I do.
"When the doctor asked me how I had found the drug I told him that for my whole life I had been living in a prison and that he had opened the gates.
"Nobody understood what it was like they couldn't see behind the great glittering career, the wonderful husband and the brilliant house."
Life
She said that at first she had been reluctant to take the anti-depressants because of the stigma attached, but said that she was glad she had persevered.
"I feel people are missing the chance to change their lives. I was in a pretty bad way a couple of years ago and it has changed my life.
"Since I have taken Seroxat I have realised that I am this bubbly person that everybody loves. I have this chemical imbalance.
"I have always had it and I will always take Seroxat."
But others fear the influence of the drug.
A spokeswoman for the Seroxat Users Group said: "We acknowledge that treatment with Seroxat is beneficial to many patients.
"Unfortunately there are an unacceptable number of patients who are suffering because they have taken Seroxat, finding themselves addicted to the drug and not infrequently overcome by suicidal ideation, resulting in the loss of life.
"The Seroxat Users Group is deeply concerned about the safety of Seroxat and is calling on the Medicines and Healthcare products Regulatory Agency (MHRA) to withdraw any new prescriptions of Seroxat until the review into its safety is complete.
"World Health Organisation statistics show that Seroxat has more reports of withdrawal difficulties and adverse reactions than any other prescribed drug, with twice as many reports as the next highest drug. The benzodiazepine Valium ranks 13th.
"There is an urgent need for independent research into the long-term effects of Seroxat, special facilities equipped to assist patient's during withdrawal, and amendment of patient and prescriber information to reflect the dangers of treatment with Seroxat."
Maker's response
A spokesperson for GlaxoSmithKline, which makes the drug, said: "Depression is a potentially deadly disease and Seroxat is an effective treatment that since launch has helped tens of millions of patients worldwide lead fuller and more productive lives.
"The majority of people do not get side effects on either taking Seroxat or on stopping.
"But some people do and we have been advising patients and doctors on what to expect, when taking or stopping treatment for many years."
Saturday, 28 March 2009
paxil payout an amazing $150 per person - about enough for 20 mins with an Amsterdam prostitute
SSRI DISCUSSION FORUM: wow !! - maximum payout an amazing $150 per person: "If approved, the $28 million settlement will be split between consumers who paid for their Paxil and insurance companies seeking to be reimbursed for their expenditures. The amount each class member recovers will depend on how many defective pills they bought, with a maximum recovery of $150 per person. A final approval hearing will be held on July 10, 2009.
Under the settlement, GlaxoSmithKline denies liability and all of the claims in the lawsuit"
Under the settlement, GlaxoSmithKline denies liability and all of the claims in the lawsuit"
Settlement Proposed in Paxil Class Action Lawsuit
Settlement Proposed in Paxil Class Action Lawsuit
http://www.newsinferno.com/archives/5327Date Published: Friday, March 27th, 2009
A settlement has been proposed in the so-called Paxil split pill class action lawsuit. According to a press release, if approved, the settlement will provide up to $28 million to claimants and their insurance companies.
Paxil is part of a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). Paxil was approved to treat symptoms of depression, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), panic disorder, generalized anxiety disorder (GAD), social phobia/social anxiety disorder, and premenstrual dysphoric disorder (PMDD). Paxil was the first antidepressant formally approved in the US for the treatment of social anxiety disorder.
The drug has been linked to a variety of problems, including birth defects, as well as suicide and suicidal tendencies when taken by young people and children. Yet in spite of these risks, by 2006 Paxil was the fifth most-commonly prescribed antidepressant in the US, with more than 19.7 million prescriptions.
The Paxil spit pill class action lawsuit alleges that Paxil controlled release (CR) tablets made between April 1, 2002 and March 4, 2005, contained a manufacturing defect that caused them to split apart. According to the complaint, Paxil CR tablets are intended to deliver the active ingredient over a period of time, and not all at once. When one splits apart, the outside coat breaks up and the drug is released while the tablets are still in the stomach. Patients end up with all of the active ingredient, without the benefits of the controlled-release, and received the entire dose at once. Or they get only the controlled-release ingredient without the active ingredients, the complaint says.
In March 2005, armed marshals with the Food and Drug Administration (FDA) raided GlaxoSmithKline plants in Puerto Rico and Tennessee after learning that some pills manufactured there had split apart. The FDA had originally discovered the problem at the Puerto Rico plant in February 2002, and the problem continued despite repeated warnings and inspections, the complaint charges.
If approved, the $28 million settlement will be split between consumers who paid for their Paxil and insurance companies seeking to be reimbursed for their expenditures. The amount each class member recovers will depend on how many defective pills they bought, with a maximum recovery of $150 per person. A final approval hearing will be held on July 10, 2009.
Under the settlement, GlaxoSmithKline denies liability and all of the claims in the lawsuit
http://www.newsinferno.com/archives/5327Date Published: Friday, March 27th, 2009
A settlement has been proposed in the so-called Paxil split pill class action lawsuit. According to a press release, if approved, the settlement will provide up to $28 million to claimants and their insurance companies.
Paxil is part of a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). Paxil was approved to treat symptoms of depression, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), panic disorder, generalized anxiety disorder (GAD), social phobia/social anxiety disorder, and premenstrual dysphoric disorder (PMDD). Paxil was the first antidepressant formally approved in the US for the treatment of social anxiety disorder.
The drug has been linked to a variety of problems, including birth defects, as well as suicide and suicidal tendencies when taken by young people and children. Yet in spite of these risks, by 2006 Paxil was the fifth most-commonly prescribed antidepressant in the US, with more than 19.7 million prescriptions.
The Paxil spit pill class action lawsuit alleges that Paxil controlled release (CR) tablets made between April 1, 2002 and March 4, 2005, contained a manufacturing defect that caused them to split apart. According to the complaint, Paxil CR tablets are intended to deliver the active ingredient over a period of time, and not all at once. When one splits apart, the outside coat breaks up and the drug is released while the tablets are still in the stomach. Patients end up with all of the active ingredient, without the benefits of the controlled-release, and received the entire dose at once. Or they get only the controlled-release ingredient without the active ingredients, the complaint says.
In March 2005, armed marshals with the Food and Drug Administration (FDA) raided GlaxoSmithKline plants in Puerto Rico and Tennessee after learning that some pills manufactured there had split apart. The FDA had originally discovered the problem at the Puerto Rico plant in February 2002, and the problem continued despite repeated warnings and inspections, the complaint charges.
If approved, the $28 million settlement will be split between consumers who paid for their Paxil and insurance companies seeking to be reimbursed for their expenditures. The amount each class member recovers will depend on how many defective pills they bought, with a maximum recovery of $150 per person. A final approval hearing will be held on July 10, 2009.
Under the settlement, GlaxoSmithKline denies liability and all of the claims in the lawsuit
Friday, 27 March 2009
Is there anyway to barter with ladies of the night ?
Q about Amsterdam - alt.rock-n-roll.acdc Google Groups: "Fiddy1 View profile Translated (View Original)
More options Dec 11 2002, 8:37 am
Newsgroups: alt.rock-n-roll.acdcFrom: 'Fiddy1' Date: Wed, 11 Dec 2002 08:37:15 GMTLocal: Wed, Dec 11 2002 8:37 am Subject: Q about AmsterdamReply to author Forward Print Individual message Show original Remove Report this message Find messages by this author
So 75 Euros is near enough £50. Is there anyway to barter with ladies of the
night?
--
Bob Fiddaman
A Member of the Seroxat Users Group
---
Outgoing mail is certified Virus Free.
SEROXAT USERS GROUP
The truth is out there
Checked by AVG anti-virus system (http://www.grisoft.com).
Version: 6.0.427 / Virus Database: 240 - Release Date: 06/12/2002"
More options Dec 11 2002, 8:37 am
Newsgroups: alt.rock-n-roll.acdcFrom: 'Fiddy1' Date: Wed, 11 Dec 2002 08:37:15 GMTLocal: Wed, Dec 11 2002 8:37 am Subject: Q about AmsterdamReply to author Forward Print Individual message Show original Remove Report this message Find messages by this author
So 75 Euros is near enough £50. Is there anyway to barter with ladies of the
night?
--
Bob Fiddaman
A Member of the Seroxat Users Group
---
Outgoing mail is certified Virus Free.
SEROXAT USERS GROUP
The truth is out there
Checked by AVG anti-virus system (http://www.grisoft.com).
Version: 6.0.427 / Virus Database: 240 - Release Date: 06/12/2002"
Will let yous know how many prossies I go through !!
Amsterdam 14 Dec - alt.rock-n-roll.acdc Google Groups: "Travelling over with a couple of mates for the Big Country fan reunion.
Stopping at the Crown Plazza - Five Star.
Will let yous know how many prossies I go through.
--
Bob Fiddaman
A Member of the Seroxat Users Group
---
Outgoing mail is certified Virus Free.
BOB 'THE CHAINSAW' FIDDAMAN
Checked by AVG anti-virus system (http://www.grisoft.com).
Version: 6.0.410 / Virus Database: 231 - Release Date: 31/10/2002"
Stopping at the Crown Plazza - Five Star.
Will let yous know how many prossies I go through.
--
Bob Fiddaman
A Member of the Seroxat Users Group
---
Outgoing mail is certified Virus Free.
BOB 'THE CHAINSAW' FIDDAMAN
Checked by AVG anti-virus system (http://www.grisoft.com).
Version: 6.0.410 / Virus Database: 231 - Release Date: 31/10/2002"
How can you get an infection in your testicle - I am married and have always stuck to one partner
Testicle pain - uk.people.health Google Groups: "I went to my GP the other day and he examined my left testicle as it was
giving me some pain and was slightly swollen. He gave me a course of
anti-biotics and told me if the pain was still there after 243 hours I was
to go straight to casualty as I might have a Torsion.
24 Hours on I went to casualty but was told that it IS NOT a Torsion but it
is more than likely an infection?
I went to my GP the other day and he examined my left testicle as it was giving me some pain and was slightly swollen. He gave me a course of anti-biotics and told me if the pain was still there after 243 hours I was to go straight to casualty as I might have a Torsion.
24 Hours on I went to casualty but was told that it IS NOT a Torsion but it is more than likely an infection?
How can you get an infection in your testicle?
I am married and have always stuck to one partner.
Any information would be greatly appreciated.
I can't remember the name he gave the infection - it was something like 'Eppidimus?'
Bob, UK
I am married and have always stuck to one partner.
Any information would be greatly appreciated.
I can't remember the name he gave the infection - it was something like
'Eppidimus?'
Bob, UK"
giving me some pain and was slightly swollen. He gave me a course of
anti-biotics and told me if the pain was still there after 243 hours I was
to go straight to casualty as I might have a Torsion.
24 Hours on I went to casualty but was told that it IS NOT a Torsion but it
is more than likely an infection?
I went to my GP the other day and he examined my left testicle as it was giving me some pain and was slightly swollen. He gave me a course of anti-biotics and told me if the pain was still there after 243 hours I was to go straight to casualty as I might have a Torsion.
24 Hours on I went to casualty but was told that it IS NOT a Torsion but it is more than likely an infection?
How can you get an infection in your testicle?
I am married and have always stuck to one partner.
Any information would be greatly appreciated.
I can't remember the name he gave the infection - it was something like 'Eppidimus?'
Bob, UK
I am married and have always stuck to one partner.
Any information would be greatly appreciated.
I can't remember the name he gave the infection - it was something like
'Eppidimus?'
Bob, UK"
Evelyn Pringle promoting Scientologist Ken Kramer - "Crusader For Kids Against TeenScreen"
Depersonalization Support Community • View topic - Ken Kramer - Crusader For Kids Against TeenScreen: "Ken Kramer - Crusader For Kids Against TeenScreen
Evelyn Pringle
The Bush appointed New Freedoms Commission on Mental Health (NFC) is urging the implementation of wide-spread screening for children to identify and treat mental illness. It wants the TeenScreen to give all children a mental health check-up before graduation from high school. Anti-Child drugging advocate, Ken Kramer, is dead-set against drugging children and therefore dead-set against TeenScreen. Kramer is an investigator for the Citizen's Commission on Human Rights (CCHR), a psychiatric watchdog group.
After thoroughly investigating TeenScreen, which calls itself as a suicide prevention program, he has come to the conclusion that the program is a drug company marketing scheme to get more kids hooked into the psychiatric system and increase the customer base for psychotropic drugs.
Kramer is sponsoring a research project to investigate the circumstances of all child suicides in the state of Florida over the past 5 years. Although the data collection is in it's infancy, Kramer says, the investigation so far has determined that between 2000-2004, 100% of children who committed suicide in Pasco County were either on psychotropic drugs or receiving psychiatric treatment.
He maintains that medicating kids with dangerous mind-altering drugs 'is the real cause of high rates of teen suicide.' Kramer recently launched an informational TeenScreen website at http://www.psychsearch.net/teenscreen.html
Evelyn Pringle
The Bush appointed New Freedoms Commission on Mental Health (NFC) is urging the implementation of wide-spread screening for children to identify and treat mental illness. It wants the TeenScreen to give all children a mental health check-up before graduation from high school. Anti-Child drugging advocate, Ken Kramer, is dead-set against drugging children and therefore dead-set against TeenScreen. Kramer is an investigator for the Citizen's Commission on Human Rights (CCHR), a psychiatric watchdog group.
After thoroughly investigating TeenScreen, which calls itself as a suicide prevention program, he has come to the conclusion that the program is a drug company marketing scheme to get more kids hooked into the psychiatric system and increase the customer base for psychotropic drugs.
Kramer is sponsoring a research project to investigate the circumstances of all child suicides in the state of Florida over the past 5 years. Although the data collection is in it's infancy, Kramer says, the investigation so far has determined that between 2000-2004, 100% of children who committed suicide in Pasco County were either on psychotropic drugs or receiving psychiatric treatment.
He maintains that medicating kids with dangerous mind-altering drugs 'is the real cause of high rates of teen suicide.' Kramer recently launched an informational TeenScreen website at http://www.psychsearch.net/teenscreen.html
Thursday, 26 March 2009
MHRA meets Bob Fiddaman - but refuses FOI request from Janne Larsson
The MHRA meets with Bob Fiddaman who failed to report that he was on a cocktail of psychoactive drugs (not just Seroxat as claimed) - yet it refused legitimate enquiry from Janne Larsson
Reporter Snöbollsgränd 22 129 45 Hägersten Sweden
Reporter Snöbollsgränd 22 129 45 Hägersten Sweden
SSRI DISCUSSION FORUM: MHRA states 'future FOIA requests will be denied on subject of STRATTERA'
SSRI DISCUSSION FORUM: MHRA states 'future FOIA requests will be denied on subject of STRATTERA': "MHRA states 'future FOIA requests will be denied on subject of STRATTERA'
March 26 2009 at 8:32 PMMHRA to deny Freedom of Information rights
Response to FURTHER email from J to Euro Commission & ccs, on data re 87 cases Strattera deaths...
But the MHRA characterizes the request as vexatious even obsessive and will not be providing an answer. In a exceptional move the agency even declares that future FOIA-requests will be denied on the subject of Strattera: We will not engage in any further correspondence with you on Strattera. (See the MHRA letter from 25 March http://jannel.se/MHRA.letter.section14.pdf )
One purpose of the FOI Act is to let citizens in on the work done by government agencies; the idea is that openness will make the work of these agencies more effective and prevent abuse of power. The answer provided by the MHRA shows a disrespect to this important law and its purpose. I can understand that the agency does not like that revealed violations of important rules are being exposed in media - but also this must be seen as a vital ingredient in a democracy. Something that in the end will mean better and safer treatment conditions for patients."
March 26 2009 at 8:32 PMMHRA to deny Freedom of Information rights
Response to FURTHER email from J to Euro Commission & ccs, on data re 87 cases Strattera deaths...
But the MHRA characterizes the request as vexatious even obsessive and will not be providing an answer. In a exceptional move the agency even declares that future FOIA-requests will be denied on the subject of Strattera: We will not engage in any further correspondence with you on Strattera. (See the MHRA letter from 25 March http://jannel.se/MHRA.letter.section14.pdf )
One purpose of the FOI Act is to let citizens in on the work done by government agencies; the idea is that openness will make the work of these agencies more effective and prevent abuse of power. The answer provided by the MHRA shows a disrespect to this important law and its purpose. I can understand that the agency does not like that revealed violations of important rules are being exposed in media - but also this must be seen as a vital ingredient in a democracy. Something that in the end will mean better and safer treatment conditions for patients."
data about 87 cases of Strattera death and MHRAs violations of important EU-rules about pharmacovigilance
data about 87 cases of Strattera death and MHRAs violations of important EU-rules about pharmacovigilance
Yesterday I sent a new report about instances of death in connection with Strattera treatment, which revealed:
87 cases of death with Strattera as Primary Suspect Drug was reported to the FDA in less than five years (between 2004 and third quarter 2008).
See the compilation:http://www.psychdrugdangers.com/StratteraDeaths2008.html
I also sent a formal complaint about MHRAs violations of important EU-rules about pharmacovigilance http://jannel.se/complaint_Strattera.death.pdf I submitted the data to the European Commission so that appropriate actions could be taken. I hoped the Commission would make certain that the important rules in the Directive would be followed, for the safety of patients.
As the MHRA today gave additonal data in the case I also want to get that information over to the Commission. In a letter written today, the day after I made my complaint to the Commission, the MHRA declares that my request for documents about Strattera deaths and the actions taken by the agency, is deemed to be vexatious (meaning, what I understand, that it is disturbing and upsetting, causing anger). The request is met with the decision we will not be providing an answer to them.
As seen in my complaint yesterday to the Commission my FOIA-request to the MHRA was a balanced request based on the rules in Volume 9A of The Rules Governing Medicinal Products in the European Union (Guidelines on Pharmacovigilance for Medicinal Products for Human Use) [1]. I wanted to get data if the MHRA, responsible for the safety of patients, and in this case mainly of children patients treated with Strattera in Europe, was adhering to the rules, when a large number of fatal results was reported for the drug. This must be seen as one of the most important applications of the FOIA.
But the MHRA characterizes the request as vexatious even obsessive and will not be providing an answer. In a exceptional move the agency even declares that future FOIA-requests will be denied on the subject of Strattera: We will not engage in any further correspondence with you on Strattera. (See the MHRA letter from 25 March http://jannel.se/MHRA.letter.section14.pdf )
One purpose of the FOI Act is to let citizens in on the work done by government agencies; the idea is that openness will make the work of these agencies more effective and prevent abuse of power. The answer provided by the MHRA shows a disrespect to this important law and its purpose. I can understand that the agency does not like that revealed violations of important rules are being exposed in media - but also this must be seen as a vital ingredient in a democracy. Something that in the end will mean better and safer treatment conditions for patients.
I consider that this answer from the MHRA, on an important request for data about Strattera deaths, makes it even more important for the Commssion to investigate the violations of the rules in the EU Directive and to take action, for the safety of patients.
Yours sincerely,
Janne Larsson
Reporter
Snöbollsgränd 22
129 45 Hägersten
Sweden
[email address]
References:
[1] European Commission, Volume 9A of The Rules Governing Medicinal Products in the European Union (Guidelines on Pharmacovigilance for Medicinal Products for Human Use) September 2008, http://ec.europa.eu/enterprise/pharmaceuticals/eudralex/vol-9/pdf/vol9a_09-2008.pdf
Yesterday I sent a new report about instances of death in connection with Strattera treatment, which revealed:
87 cases of death with Strattera as Primary Suspect Drug was reported to the FDA in less than five years (between 2004 and third quarter 2008).
See the compilation:http://www.psychdrugdangers.com/StratteraDeaths2008.html
I also sent a formal complaint about MHRAs violations of important EU-rules about pharmacovigilance http://jannel.se/complaint_Strattera.death.pdf I submitted the data to the European Commission so that appropriate actions could be taken. I hoped the Commission would make certain that the important rules in the Directive would be followed, for the safety of patients.
As the MHRA today gave additonal data in the case I also want to get that information over to the Commission. In a letter written today, the day after I made my complaint to the Commission, the MHRA declares that my request for documents about Strattera deaths and the actions taken by the agency, is deemed to be vexatious (meaning, what I understand, that it is disturbing and upsetting, causing anger). The request is met with the decision we will not be providing an answer to them.
As seen in my complaint yesterday to the Commission my FOIA-request to the MHRA was a balanced request based on the rules in Volume 9A of The Rules Governing Medicinal Products in the European Union (Guidelines on Pharmacovigilance for Medicinal Products for Human Use) [1]. I wanted to get data if the MHRA, responsible for the safety of patients, and in this case mainly of children patients treated with Strattera in Europe, was adhering to the rules, when a large number of fatal results was reported for the drug. This must be seen as one of the most important applications of the FOIA.
But the MHRA characterizes the request as vexatious even obsessive and will not be providing an answer. In a exceptional move the agency even declares that future FOIA-requests will be denied on the subject of Strattera: We will not engage in any further correspondence with you on Strattera. (See the MHRA letter from 25 March http://jannel.se/MHRA.letter.section14.pdf )
One purpose of the FOI Act is to let citizens in on the work done by government agencies; the idea is that openness will make the work of these agencies more effective and prevent abuse of power. The answer provided by the MHRA shows a disrespect to this important law and its purpose. I can understand that the agency does not like that revealed violations of important rules are being exposed in media - but also this must be seen as a vital ingredient in a democracy. Something that in the end will mean better and safer treatment conditions for patients.
I consider that this answer from the MHRA, on an important request for data about Strattera deaths, makes it even more important for the Commssion to investigate the violations of the rules in the EU Directive and to take action, for the safety of patients.
Yours sincerely,
Janne Larsson
Reporter
Snöbollsgränd 22
129 45 Hägersten
Sweden
[email address]
References:
[1] European Commission, Volume 9A of The Rules Governing Medicinal Products in the European Union (Guidelines on Pharmacovigilance for Medicinal Products for Human Use) September 2008, http://ec.europa.eu/enterprise/pharmaceuticals/eudralex/vol-9/pdf/vol9a_09-2008.pdf
Wednesday, 25 March 2009
If Clozapine kills 5.6 times more on 238 times less scripts than Seroxat - it must be 1300 times more dangerous
CLOZAPINE Total number of ADR reports: 11560 Total number of fatal ADR reports: 935Response to Download Drug Analysis Prints (DAPs)http://www.mhra.gov.uk/home/groups/public/documents/sentineldocum
Seroxat/ParoxetineTotal number of ADR reports: 10369 Total number of fatal ADR reports: 166
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235564897002.pdfTotal number of ADR reports: 10369 Total number of fatal ADR reports: 166
Drug preparations, dressings and appliances listed alphabetically within British National Formulary classifications England 2007Seroxat_Tab 10mg 3 19.6 18.1 285.0 647.7 1 14.53 0.44 33.03Seroxat_Tab 20mg 3 37.2 0.0 673.3 1,529.0 1 18.08 0.44 41.06Seroxat_Tab 30mg 3 10.6 0.0 318.5 412.2 1 30.14 0.77 39.02Total for chemical entity : Paroxetine Hydrochloride 1,765.9 57.4 15,552.6 8.81see page 122 / 619http://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdf
about 7400 Clozapine scripts in England 2007 for a drug that kills 1 per week
seehttp://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdfpage 111 / 619Clozaril_Tab 100mg 3 2.5 1.8 214.7 244.4 1 85.59 0.88 97.40Clozaril_Tab 25mg 3 1.6 1.1 22.7 102.2 1 14.57 0.22 65.68Denzapine_Tab 100mg 3 1.2 1.0 84.1 95.5 1 70.53 0.88 80.15Denzapine_Tab 25mg 3 0.6 0.5 8.6 38.9 1 13.46 0.22 61.12Zaponex_Tab 100mg 3 0.9 0.8 21.3 33.2 1 24.97 0.64 38.90Zaponex_Tab 25mg 3 0.7 0.6 3.5 16.5 1 5.35 0.21 24.94Total for chemical entity : Clozapine 7.4 6.0 354.9 47.91
Seroxat/ParoxetineTotal number of ADR reports: 10369 Total number of fatal ADR reports: 166
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235564897002.pdfTotal number of ADR reports: 10369 Total number of fatal ADR reports: 166
Drug preparations, dressings and appliances listed alphabetically within British National Formulary classifications England 2007Seroxat_Tab 10mg 3 19.6 18.1 285.0 647.7 1 14.53 0.44 33.03Seroxat_Tab 20mg 3 37.2 0.0 673.3 1,529.0 1 18.08 0.44 41.06Seroxat_Tab 30mg 3 10.6 0.0 318.5 412.2 1 30.14 0.77 39.02Total for chemical entity : Paroxetine Hydrochloride 1,765.9 57.4 15,552.6 8.81see page 122 / 619http://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdf
about 7400 Clozapine scripts in England 2007 for a drug that kills 1 per week
seehttp://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdfpage 111 / 619Clozaril_Tab 100mg 3 2.5 1.8 214.7 244.4 1 85.59 0.88 97.40Clozaril_Tab 25mg 3 1.6 1.1 22.7 102.2 1 14.57 0.22 65.68Denzapine_Tab 100mg 3 1.2 1.0 84.1 95.5 1 70.53 0.88 80.15Denzapine_Tab 25mg 3 0.6 0.5 8.6 38.9 1 13.46 0.22 61.12Zaponex_Tab 100mg 3 0.9 0.8 21.3 33.2 1 24.97 0.64 38.90Zaponex_Tab 25mg 3 0.7 0.6 3.5 16.5 1 5.35 0.21 24.94Total for chemical entity : Clozapine 7.4 6.0 354.9 47.91
so a drug (Seroxat) that is prescribed 238.5 times more than clozapine kills 5.6 times less
so why is the regulator sucking up to benefit cheats & ambulance chasing lawyers
CLOZAPINE Total number of ADR reports: 11560 Total number of fatal ADR reports: 936
CLOZAPINE Total number of ADR reports: 11560 Total number of fatal ADR reports: 935
Response to Download Drug Analysis Prints (DAPs)
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235557933291.pdf
Response to Download Drug Analysis Prints (DAPs)
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235557933291.pdf
Seroxat/ParoxetineTotal number of ADR reports: 10369 Total number of fatal ADR reports: 166
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235564897002.pdf
Total number of ADR reports: 10369 Total number of fatal ADR reports: 166
Total number of ADR reports: 10369 Total number of fatal ADR reports: 166
2007 Seroxat scripts = 1,765.9 x 1000 i.e. 238.5 times greater than Clozapine
Drug preparations, dressings and appliances listed alphabetically within British National Formulary classifications England 2007
Seroxat_Tab 10mg 3 19.6 18.1 285.0 647.7 1 14.53 0.44 33.03
Seroxat_Tab 20mg 3 37.2 0.0 673.3 1,529.0 1 18.08 0.44 41.06
Seroxat_Tab 30mg 3 10.6 0.0 318.5 412.2 1 30.14 0.77 39.02
Total for chemical entity : Paroxetine Hydrochloride 1,765.9 57.4 15,552.6 8.81
see page 122 / 619
http://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdf
Seroxat_Tab 10mg 3 19.6 18.1 285.0 647.7 1 14.53 0.44 33.03
Seroxat_Tab 20mg 3 37.2 0.0 673.3 1,529.0 1 18.08 0.44 41.06
Seroxat_Tab 30mg 3 10.6 0.0 318.5 412.2 1 30.14 0.77 39.02
Total for chemical entity : Paroxetine Hydrochloride 1,765.9 57.4 15,552.6 8.81
see page 122 / 619
http://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdf
about 7400 Clozapine scripts in England 2007 for a drug that kills 1 per week
see
http://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdf
page 111 / 619
Clozaril_Tab 100mg 3 2.5 1.8 214.7 244.4 1 85.59 0.88 97.40
Clozaril_Tab 25mg 3 1.6 1.1 22.7 102.2 1 14.57 0.22 65.68
Denzapine_Tab 100mg 3 1.2 1.0 84.1 95.5 1 70.53 0.88 80.15
Denzapine_Tab 25mg 3 0.6 0.5 8.6 38.9 1 13.46 0.22 61.12
Zaponex_Tab 100mg 3 0.9 0.8 21.3 33.2 1 24.97 0.64 38.90
Zaponex_Tab 25mg 3 0.7 0.6 3.5 16.5 1 5.35 0.21 24.94
Total for chemical entity : Clozapine 7.4 6.0 354.9 47.91
Mind, the mental health charity, which analysed the figures, said that the number of deaths associated with the drug was chilling. The MHRA promised to look into the charitys concerns.
The warning comes as the National Institute for Health and Clinical Excellence (NICE) is due to publish guidelines tomorrow on the treatment of schizophrenia, which affects about one in every 100 people in Britain. The watchdog will recommend that oral anti-psychotic medications should be offered to people with newly diagnosed schizophrenia, although patients should take clozapine only after trying at least two other drugs.
The drug, also known by the brand names Clozaril, Denzapine and Zaponex, was prescribed on 7,000 occasions last year many of which will have been repeat prescriptions to help to control delusions and hallucinations.
http://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdf
page 111 / 619
Clozaril_Tab 100mg 3 2.5 1.8 214.7 244.4 1 85.59 0.88 97.40
Clozaril_Tab 25mg 3 1.6 1.1 22.7 102.2 1 14.57 0.22 65.68
Denzapine_Tab 100mg 3 1.2 1.0 84.1 95.5 1 70.53 0.88 80.15
Denzapine_Tab 25mg 3 0.6 0.5 8.6 38.9 1 13.46 0.22 61.12
Zaponex_Tab 100mg 3 0.9 0.8 21.3 33.2 1 24.97 0.64 38.90
Zaponex_Tab 25mg 3 0.7 0.6 3.5 16.5 1 5.35 0.21 24.94
Total for chemical entity : Clozapine 7.4 6.0 354.9 47.91
Mind, the mental health charity, which analysed the figures, said that the number of deaths associated with the drug was chilling. The MHRA promised to look into the charitys concerns.
The warning comes as the National Institute for Health and Clinical Excellence (NICE) is due to publish guidelines tomorrow on the treatment of schizophrenia, which affects about one in every 100 people in Britain. The watchdog will recommend that oral anti-psychotic medications should be offered to people with newly diagnosed schizophrenia, although patients should take clozapine only after trying at least two other drugs.
The drug, also known by the brand names Clozaril, Denzapine and Zaponex, was prescribed on 7,000 occasions last year many of which will have been repeat prescriptions to help to control delusions and hallucinations.
MHRA admits clozapine linked to 950 deaths since being licensed in 1990
MHRA admits clozapine linked to 950 deaths since being licensed in 1990March 24 2009 at 10:20 PM
Anonymous
http://www.timesonline.co.uk/tol/life_and_style/health/mental_health/article5968642.ece
From Times Online March 24, 2009
Hundreds of deaths linked to schizophrenia drug clozapine
David Rose
Fifty people die each year and hundreds more suffer serious side-effects as the result of taking powerful tranquillisers prescribed by the NHS, The Times has learnt.
Data from the medicine watchdogs own reporting scheme suggests that clozapine, a drug taken by schizophrenia patients, has been linked to 950 deaths since being licensed in 1990 equivalent to nearly one fatality a week.
Recent figures record the deaths of 55 people taking the medication in four months, from October to January, despite the drug being prescribed to relatively few people.
The anti-psychotic drug is used as a treatment of last resort for schizophrenia patients but appears to increase the chances of having a heart attack or stroke, or of suffering other long-term health problems that are not adequately monitored by current checks, campaigners say. More than 11,600 adverse reactions linked to clozapine have been reported in 19 years, according to the Yellow Card reporting scheme of the Medicines and Healthcare products Regulatory Agency (MHRA), which is designed to flag up potentially harmful side-effects for licensed drugs.
Related Links
Schizophrenia is the modern leprosy
Children given unlicensed anti-psychotic drugs
Mind, the mental health charity, which analysed the figures, said that the number of deaths associated with the drug was chilling. The MHRA promised to look into the charitys concerns.
The warning comes as the National Institute for Health and Clinical Excellence (NICE) is due to publish guidelines tomorrow on the treatment of schizophrenia, which affects about one in every 100 people in Britain. The watchdog will recommend that oral anti-psychotic medications should be offered to people with newly diagnosed schizophrenia, although patients should take clozapine only after trying at least two other drugs.
The drug, also known by the brand names Clozaril, Denzapine and Zaponex, was prescribed on 7,000 occasions last year many of which will have been repeat prescriptions to help to control delusions and hallucinations.
People who take clozapine must be given regular blood monitoring for the risk of a potentially fatal blood disorder known as agranulocytosis, but at present there is no mandatory requirement to monitor their health in other ways.
NICE will recommend tomorrow that GPs and other primary healthcare professionals should monitor the physical health of people with schizophrenia at least once a year, with a focus on their risks of heart disease.
Alison Cobb, senior policy officer at Mind, said that the drug could be effective for some patients and acknowledged that people with schizophrenia had a higher risk of death than the general population. There are health risks and side-effects associated with all anti-psychotic medications but it is chilling to see this number of deaths associated with clozapine and the month-on-month increases, she said. The figures refer to heart disease, strokes, cancer and other long-term health problems that cannot be explained simply by suicides or an increased overall risk of death.
We want to see the use of clozapine properly reviewed and for people taking it to be offered the full range of health checks and alternative treatment options that might mitigate any harmful effects.
A study published in the British Journal of Psychiatry last month concluded that use of clozapine in patients with severe mental illness was associated with a significantly increased risk of death compared with the general population. However, the author of the study, David Taylor, the chief pharmacist at Maudsley Hospital, South London, defended the use of the drug, which he said had transformed the lives of thousands of people around the world.
Most of the deaths reported could not be said to be a result of clozapine treatment; none could be definitively linked to its use, he said. Clozapine, it is widely agreed, is under-used in this country and in practice its use is delayed for much longer than NICE currently recommend.
The safety of clozapine has been continuously monitored since its launch in 1990, he added. In fact, no other drug has been as closely monitored. Close and intensive physical monitoring should be mandatory for all people with severe mental illness, regardless of treatment.
In a statement, the MHRA added: We are aware of the particular concerns of Mind in relation to clozapine and have already indicated to them that we will look further into the concerns they have raised and consider whether the trends in reporting through the Yellow Card scheme raise any new issues that merit update to the product information or indeed require reminders to prescribers about the need for close monitoring of patients to optimise safe use."
Simon Hough was diagnosed with schizophrenia 14 years ago and still manages his condition with medication. Fellow patients warned him off clozapine, after those taking it compared the effects to like coming off cocaine or heroin.
They described feeling really low and lethargic, and the side-effects such as weight gain and dry mouth were so much worse than other drugs, he said. One guy I knew was average weight, about 10 or 11 stone, and he just ballooned up to about 18 or 19 stone when he started taking the drug. Thats got to have some impact on your long-term health.
Mr Hough, 42, who now works for Making Space, a mental health charity in Northwich, Cheshire, took part in the CUtLASS study, a large-scale trial comparing the effects of modern antipsychotic drugs with those of older treatments.
I was offered clozapine but after all that Id heard about it I preferred to be in the group that took quetiapine [an alternative drug] instead
Anonymous
http://www.timesonline.co.uk/tol/life_and_style/health/mental_health/article5968642.ece
From Times Online March 24, 2009
Hundreds of deaths linked to schizophrenia drug clozapine
David Rose
Fifty people die each year and hundreds more suffer serious side-effects as the result of taking powerful tranquillisers prescribed by the NHS, The Times has learnt.
Data from the medicine watchdogs own reporting scheme suggests that clozapine, a drug taken by schizophrenia patients, has been linked to 950 deaths since being licensed in 1990 equivalent to nearly one fatality a week.
Recent figures record the deaths of 55 people taking the medication in four months, from October to January, despite the drug being prescribed to relatively few people.
The anti-psychotic drug is used as a treatment of last resort for schizophrenia patients but appears to increase the chances of having a heart attack or stroke, or of suffering other long-term health problems that are not adequately monitored by current checks, campaigners say. More than 11,600 adverse reactions linked to clozapine have been reported in 19 years, according to the Yellow Card reporting scheme of the Medicines and Healthcare products Regulatory Agency (MHRA), which is designed to flag up potentially harmful side-effects for licensed drugs.
Related Links
Schizophrenia is the modern leprosy
Children given unlicensed anti-psychotic drugs
Mind, the mental health charity, which analysed the figures, said that the number of deaths associated with the drug was chilling. The MHRA promised to look into the charitys concerns.
The warning comes as the National Institute for Health and Clinical Excellence (NICE) is due to publish guidelines tomorrow on the treatment of schizophrenia, which affects about one in every 100 people in Britain. The watchdog will recommend that oral anti-psychotic medications should be offered to people with newly diagnosed schizophrenia, although patients should take clozapine only after trying at least two other drugs.
The drug, also known by the brand names Clozaril, Denzapine and Zaponex, was prescribed on 7,000 occasions last year many of which will have been repeat prescriptions to help to control delusions and hallucinations.
People who take clozapine must be given regular blood monitoring for the risk of a potentially fatal blood disorder known as agranulocytosis, but at present there is no mandatory requirement to monitor their health in other ways.
NICE will recommend tomorrow that GPs and other primary healthcare professionals should monitor the physical health of people with schizophrenia at least once a year, with a focus on their risks of heart disease.
Alison Cobb, senior policy officer at Mind, said that the drug could be effective for some patients and acknowledged that people with schizophrenia had a higher risk of death than the general population. There are health risks and side-effects associated with all anti-psychotic medications but it is chilling to see this number of deaths associated with clozapine and the month-on-month increases, she said. The figures refer to heart disease, strokes, cancer and other long-term health problems that cannot be explained simply by suicides or an increased overall risk of death.
We want to see the use of clozapine properly reviewed and for people taking it to be offered the full range of health checks and alternative treatment options that might mitigate any harmful effects.
A study published in the British Journal of Psychiatry last month concluded that use of clozapine in patients with severe mental illness was associated with a significantly increased risk of death compared with the general population. However, the author of the study, David Taylor, the chief pharmacist at Maudsley Hospital, South London, defended the use of the drug, which he said had transformed the lives of thousands of people around the world.
Most of the deaths reported could not be said to be a result of clozapine treatment; none could be definitively linked to its use, he said. Clozapine, it is widely agreed, is under-used in this country and in practice its use is delayed for much longer than NICE currently recommend.
The safety of clozapine has been continuously monitored since its launch in 1990, he added. In fact, no other drug has been as closely monitored. Close and intensive physical monitoring should be mandatory for all people with severe mental illness, regardless of treatment.
In a statement, the MHRA added: We are aware of the particular concerns of Mind in relation to clozapine and have already indicated to them that we will look further into the concerns they have raised and consider whether the trends in reporting through the Yellow Card scheme raise any new issues that merit update to the product information or indeed require reminders to prescribers about the need for close monitoring of patients to optimise safe use."
Simon Hough was diagnosed with schizophrenia 14 years ago and still manages his condition with medication. Fellow patients warned him off clozapine, after those taking it compared the effects to like coming off cocaine or heroin.
They described feeling really low and lethargic, and the side-effects such as weight gain and dry mouth were so much worse than other drugs, he said. One guy I knew was average weight, about 10 or 11 stone, and he just ballooned up to about 18 or 19 stone when he started taking the drug. Thats got to have some impact on your long-term health.
Mr Hough, 42, who now works for Making Space, a mental health charity in Northwich, Cheshire, took part in the CUtLASS study, a large-scale trial comparing the effects of modern antipsychotic drugs with those of older treatments.
I was offered clozapine but after all that Id heard about it I preferred to be in the group that took quetiapine [an alternative drug] instead
SSRI DISCUSSION FORUM: Hauptbefehlsleiter Kunt Voods - Reichsarbeitsgemeinschaft Heil- und Pflegeanstalten
SSRI DISCUSSION FORUM: Hauptbefehlsleiter Kunt Voods - Reichsarbeitsgemeinschaft Heil- und Pflegeanstalten: "Hauptbefehlsleiter Kunt Voods - Reichsarbeitsgemeinschaft Heil- und Pflegeanstalten
March 25 2009 at 1:05 PMAnonymous
Response to T4 Medical Killing Program
Hauptbefehlsleiter Kunt Voods
Reichsarbeitsgemeinschaft Heil- und Pflegeanstalten"
March 25 2009 at 1:05 PMAnonymous
Response to T4 Medical Killing Program
Hauptbefehlsleiter Kunt Voods
Reichsarbeitsgemeinschaft Heil- und Pflegeanstalten"
SSRI DISCUSSION FORUM: NHS electronic library shows - Antipsychotics double risk of sudden cardiac death
SSRI DISCUSSION FORUM: NHS electronic library shows - Antipsychotics double risk of sudden cardiac death: "RETURN TO MESSAGES INDEX
NHS electronic library shows - Antipsychotics double risk of sudden cardiac death
March 25 2009 at 10:56 AMAnonymous
Response to MHRA ignores drug safety for psychiatric patients
Use of antipsychotic drugs was associated with about twice the rate of sudden cardiac death as that in non-users NeLM news service Sudden cardiac death with antipsychotics - risk is similar for typical and atypical drugs
Reference: N Engl J Med 2009; 360: 225-35, 294-6
Source: N Engl J Med
Date published: 15/01/2009 14:40
Summary by: Jim Glare
A large epidemiological study indicates that current users of antipsychotic drugs are at increased risk of sudden cardiac death, and that the increased risk is similar for both typical and atypical agents"
http://www.nelm.nhs.uk/en/NeLM-Area/News/2009---January/15/Sudden-cardiac-death-with-antipsychotics---risk-is-similar-for-typical-and-atypical-drugs/
NHS electronic library shows - Antipsychotics double risk of sudden cardiac death
March 25 2009 at 10:56 AMAnonymous
Response to MHRA ignores drug safety for psychiatric patients
Use of antipsychotic drugs was associated with about twice the rate of sudden cardiac death as that in non-users NeLM news service Sudden cardiac death with antipsychotics - risk is similar for typical and atypical drugs
Reference: N Engl J Med 2009; 360: 225-35, 294-6
Source: N Engl J Med
Date published: 15/01/2009 14:40
Summary by: Jim Glare
A large epidemiological study indicates that current users of antipsychotic drugs are at increased risk of sudden cardiac death, and that the increased risk is similar for both typical and atypical agents"
http://www.nelm.nhs.uk/en/NeLM-Area/News/2009---January/15/Sudden-cardiac-death-with-antipsychotics---risk-is-similar-for-typical-and-atypical-drugs/
SSRI DISCUSSION FORUM: OlanzapineTotal number of ADR reports: 2366 Total number of fatal ADR reports: 162
SSRI DISCUSSION FORUM: OlanzapineTotal number of ADR reports: 2366 Total number of fatal ADR reports: 162: "OlanzapineTotal number of ADR reports: 2366 Total number of fatal ADR reports: 162
March 25 2009 at 10:26 AMEli Lilly's Olanzapine KILLS psych patients
Response to MHRA ignores drug safety for psychiatric patients
Total number of ADR reports: 2366 Total number of fatal ADR reports: 162
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235564888788.pdf
Olanzapine = Zyprexa"
March 25 2009 at 10:26 AMEli Lilly's Olanzapine KILLS psych patients
Response to MHRA ignores drug safety for psychiatric patients
Total number of ADR reports: 2366 Total number of fatal ADR reports: 162
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235564888788.pdf
Olanzapine = Zyprexa"
SSRI DISCUSSION FORUM: CLOZAPINE Total number of ADR reports: 11560 Total number of fatal ADR reports: 936
SSRI DISCUSSION FORUM: CLOZAPINE Total number of ADR reports: 11560 Total number of fatal ADR reports: 936: "CLOZAPINE Total number of ADR reports: 11560 Total number of fatal ADR reports: 936
March 24 2009 at 10:40 PMAnonymous
Response to Download Drug Analysis Prints (DAPs)
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235557933291.pdf"
March 24 2009 at 10:40 PMAnonymous
Response to Download Drug Analysis Prints (DAPs)
http://www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1235557933291.pdf"
SSRI DISCUSSION FORUM: Euthanasia - the "mercy killing" of people "not worth living"
SSRI DISCUSSION FORUM: Euthanasia - the "mercy killing" of people "not worth living": "Euthanasia - the 'mercy killing' of people 'not worth living' became a murderous program in Nazi Germany. This campaign is believed to have resulted in the killing of approximately 200,000 people. Evidence from the Nuremburg trials estimated that even 275,000 people were murdered.
Order from 18 August 1939
1 September 1939
According to the decree from 18 August 1939, the Nazis enacted the obligatory registration of all births of physically and mentally handicapped children. These children up to three years had to be reported to the public health offices. The selected children were sent to several mental homes where they were killed by lethal drugs or withdrawal of food.
Up to 8,000 children lost their lives in course of this 'children euthanasia'. On the basis of Hitler's order from October 1939 the program was extended on adults. This order was backdated on 1 September 1939, day of the German attack on Poland. The beginning of WW2 diverted the population from the euthanasia programme. The Nazis could get rid of 'useless eaters' to save money and personnel, and get more free beds in hospitals.
In course of the occupation of Poland mobile gas chambers were used for the killing of mental homes inmates there.
Already in 1924/25 Hitler wrote 'if there is no more power to fight for the own health, the right to live comes to an end.' (Hitler, Adolf. Mein Kampf, p.282). The benefit of eliminating approximately 70,000 handicapped persons was mentioned by Hitler on the NSDAP party conference in 1929."
Order from 18 August 1939
1 September 1939
According to the decree from 18 August 1939, the Nazis enacted the obligatory registration of all births of physically and mentally handicapped children. These children up to three years had to be reported to the public health offices. The selected children were sent to several mental homes where they were killed by lethal drugs or withdrawal of food.
Up to 8,000 children lost their lives in course of this 'children euthanasia'. On the basis of Hitler's order from October 1939 the program was extended on adults. This order was backdated on 1 September 1939, day of the German attack on Poland. The beginning of WW2 diverted the population from the euthanasia programme. The Nazis could get rid of 'useless eaters' to save money and personnel, and get more free beds in hospitals.
In course of the occupation of Poland mobile gas chambers were used for the killing of mental homes inmates there.
Already in 1924/25 Hitler wrote 'if there is no more power to fight for the own health, the right to live comes to an end.' (Hitler, Adolf. Mein Kampf, p.282). The benefit of eliminating approximately 70,000 handicapped persons was mentioned by Hitler on the NSDAP party conference in 1929."
T4 Medical Killing Program - or how to deal with problem psychiatric patients
T4 Medical Killing Program
http://remember.org/witness/wit.vic.med.html
The camouflage organization created for the medical killing of adults was known as the Reich Work Group of Sanatoriums and Nursing Homes (Reichsarbeitsgemeinschaft Heil- und Pflegeanstalten, or RAG). It operated from the Berlin Chancellery, at Tiergarten 4, hence the "T4" code name. In time, word of the Nazi T4 program (medical killing on a vast scale) filtered down into the general population, and resistance began to emerge. In time, after scathing denouncements by clergy, and even Werner Moelders, a Catholic Luftwaffe pilot and war hero (who threatened to return his decorations if the `euthanasia' program was not halted), the decision was made to respond...."Nazi leaders faced the prospect of either having to imprison prominent, highly admired clergymen and other protesters _ a course with consequences in terms of adverse public reaction they greatly feared _ or else end the program. The latter was essentially the recommendation of Himmler, who noted that the secret was no longer a secret, though added, `If operation T4 had been entrusted to the SS, things would have happened differently, 'because `when the Fuehrer entrusts us with a job, we know how to deal with it correctly, without causing useless uproar among the people.'<51> "Early in 1941, T4 leader Bouhler agreed to let Himmler use T4 personnel and facilities to rid the camps of `excess' prisoners _ notably those most seriously ill,' physically and mentally. Sometimes called `prisoner euthanasia' or (by prisoners) `Operation Invalid,' the resultant program was officially `Operation [or Special Treatment] 14f13.'* The designation came from the reference number for the operation in documents of the Concentration Camp Inspectorate.** That spring, `experimental psychiatrists' from T4 were sent to the camps, assured that their work in selecting out `asocial' elements had scientific importance. Their work, as in T4, was based on prior questionnaires. For this purpose, however, they were shorter, asking after a prisoner's name, race, and `health' (that is, whether incurable). *** The short form was explained by the T4 doctors' lack of time, although camp commandants or camp doctors did the initial screening. To camouflage procedures, those selected were told that they were being sent to a `rest home.' (In fact, people apparently volunteered until it was realized what was happening when personal effects, but no rested' prisoners, returned.)<6>
As low as T4 standards were, those in 14f13 were worse. `Examinations' by T4 doctors were perfunctory or non-existent, and the questionnaires frequently contained no medical information at all, but only a list of an inmate's ostensible crimes and political deviations. Ordinary SS camp personnel could construe political beliefs or rude comments about the Fuehrer as `mental deficiency' or `psychological aberration,' and the visiting doctors' commission almost never objected to an SS request for transfer' (to a killing facility). Whatever the travesty of medicine, inmates observed that `the doctors were dressed in white coats,' although other prisoners apparently assumed that they were Gestapo in disguise.<7>
Hitler apparently gave Brandt a verbal order on or about 24 August 1941 to end or at least `stall' operation T4.<52> But the killing of mental patients did not end: mass murder was just beginning. What was discontinued was only the visible dimension of the project: the large-scale gassing of patients. T4 officially ceased as a program, but that turned out to be still another deception. Widespread killing continued in a second phase, sometimes referred to in Nazi documents as `wild euthanasia' because doctors _ encouraged, if not directed, by the regime_ could now act on their own initiative concerning who would live or die.<1>
While the regime ordered most of the gas chambers dismantled (to be reassembled, as it turned out, in the East), it did nothing to stop the ideological and institutional momentum of medical killing. The regime's clear message, in fact, was that the killings were to go on, but more quietly. And more quiet killing meant more isolated, individual procedures. Doctors acted on their personal and ideological inclinations, along with their sense of the regime's pulse. That pulse emanated no longer from the Chancellery, which bowed out along with T4 itself, but from the Reich Interior Ministry and its national medical subdivision. There were changes in geographical location, but the regime continued to make transportation arrangements, required that patients' deaths be recorded centrally, and in some cases maintained T4 experts in a partially supervisory role. Patients were now killed not by gas but by starvation and drugs, the latter method in particular rendering the killing still more `medical.' The children's program was not included under the T4 `halt.'
Killing methods did not have to be changed: drugs and starvation, and not gas, had been employed from the beginning. The killing of children had been considerably less visible, taking place as it did on wards in smaller facilities without the telltale evidence of noxious smoke and odors that stemmed from large-scale gassing. The programs had been based more on presumed eugenic and scientific grounds than on direct economic ones (the children did not work and ate less) and had not created the degree of public controversy that adult killing had. If anything, the reporting methods for ostensible abnormalities became more systematic. Research efforts, mostly post-mortem studies, also became more systematic, as sometimes happened in adult `wild euthanasia.'
Not only did the regime remain closely involved, but the greater part of the killing of children took place after the official ending of the `euthanasia' project. What did become more `wild' was the method of deciding which children should be killed. Now even the pretense of review boards of `expert opinion' was abandoned: any child considered in some way impaired, and sent though the administrative system to any of the `special pediatric units' of the original project, was still fair game. Beyond that, institutional doctors could proceed according to their own inclinations.
Adult `wild euthanasia' involved more radical changes for psychiatrists. No longer operators of gas chambers, they returned to the familiar terrain of syringes, oral medications, and dietary prescriptions of achieving the same end. From the regime's medical bureaucracy came the continuing message that mental patients were `useless eaters,' burdens on the state and its war effort, `life unworthy of life.' Permission to kill was clear enough, even if a little indirect. As one psychiatrist later testified, `In conversation with other participants in the program I learned that there would be no fuss if some physician or other in an institution stood ready to kill a patient by injection or overdose, if he was convinced that the patient's extinction was desirable.' And there was a partial merger of child and adult `euthanasia' programs as the age limit of the children's program was raised to sixteen years: `to some extent this expansion was to offer a substitute for the canceled program.'<2> There were, in fact, documented cases of patients of about that age who had managed to survive the official end of the adult `euthanasia' program only to be fatally reclassified as a child.<3><52> Hefelmann testimony, 6-15 September 1960, Heyde Trial, pp. 681-82. See also p. 680<1> Ernst Klee, "Euthansie" im NS-Staat: Die "Vernichtung lebensunwerten Lebens" (Frankfurt/M: S. Fischer, 1983, p. 440)<2> Friedrich Mennecke, quoted in Alexander Mitscherlich and Fred Mielke, "Doctors of Infamy: The Story of the Nazi Medical Crimes" (New York:n Henry Schuman, 1949) p. 116
Extracted from THE NAZI DOCTORS: Medical Killing and the Psychology of Genocide.Lifton, Robert Jay, London: Papermac, 1986 (Reprinted 1990)__pp.95-97
http://remember.org/witness/wit.vic.med.html
The camouflage organization created for the medical killing of adults was known as the Reich Work Group of Sanatoriums and Nursing Homes (Reichsarbeitsgemeinschaft Heil- und Pflegeanstalten, or RAG). It operated from the Berlin Chancellery, at Tiergarten 4, hence the "T4" code name. In time, word of the Nazi T4 program (medical killing on a vast scale) filtered down into the general population, and resistance began to emerge. In time, after scathing denouncements by clergy, and even Werner Moelders, a Catholic Luftwaffe pilot and war hero (who threatened to return his decorations if the `euthanasia' program was not halted), the decision was made to respond...."Nazi leaders faced the prospect of either having to imprison prominent, highly admired clergymen and other protesters _ a course with consequences in terms of adverse public reaction they greatly feared _ or else end the program. The latter was essentially the recommendation of Himmler, who noted that the secret was no longer a secret, though added, `If operation T4 had been entrusted to the SS, things would have happened differently, 'because `when the Fuehrer entrusts us with a job, we know how to deal with it correctly, without causing useless uproar among the people.'<51> "Early in 1941, T4 leader Bouhler agreed to let Himmler use T4 personnel and facilities to rid the camps of `excess' prisoners _ notably those most seriously ill,' physically and mentally. Sometimes called `prisoner euthanasia' or (by prisoners) `Operation Invalid,' the resultant program was officially `Operation [or Special Treatment] 14f13.'* The designation came from the reference number for the operation in documents of the Concentration Camp Inspectorate.** That spring, `experimental psychiatrists' from T4 were sent to the camps, assured that their work in selecting out `asocial' elements had scientific importance. Their work, as in T4, was based on prior questionnaires. For this purpose, however, they were shorter, asking after a prisoner's name, race, and `health' (that is, whether incurable). *** The short form was explained by the T4 doctors' lack of time, although camp commandants or camp doctors did the initial screening. To camouflage procedures, those selected were told that they were being sent to a `rest home.' (In fact, people apparently volunteered until it was realized what was happening when personal effects, but no rested' prisoners, returned.)<6>
As low as T4 standards were, those in 14f13 were worse. `Examinations' by T4 doctors were perfunctory or non-existent, and the questionnaires frequently contained no medical information at all, but only a list of an inmate's ostensible crimes and political deviations. Ordinary SS camp personnel could construe political beliefs or rude comments about the Fuehrer as `mental deficiency' or `psychological aberration,' and the visiting doctors' commission almost never objected to an SS request for transfer' (to a killing facility). Whatever the travesty of medicine, inmates observed that `the doctors were dressed in white coats,' although other prisoners apparently assumed that they were Gestapo in disguise.<7>
Hitler apparently gave Brandt a verbal order on or about 24 August 1941 to end or at least `stall' operation T4.<52> But the killing of mental patients did not end: mass murder was just beginning. What was discontinued was only the visible dimension of the project: the large-scale gassing of patients. T4 officially ceased as a program, but that turned out to be still another deception. Widespread killing continued in a second phase, sometimes referred to in Nazi documents as `wild euthanasia' because doctors _ encouraged, if not directed, by the regime_ could now act on their own initiative concerning who would live or die.<1>
While the regime ordered most of the gas chambers dismantled (to be reassembled, as it turned out, in the East), it did nothing to stop the ideological and institutional momentum of medical killing. The regime's clear message, in fact, was that the killings were to go on, but more quietly. And more quiet killing meant more isolated, individual procedures. Doctors acted on their personal and ideological inclinations, along with their sense of the regime's pulse. That pulse emanated no longer from the Chancellery, which bowed out along with T4 itself, but from the Reich Interior Ministry and its national medical subdivision. There were changes in geographical location, but the regime continued to make transportation arrangements, required that patients' deaths be recorded centrally, and in some cases maintained T4 experts in a partially supervisory role. Patients were now killed not by gas but by starvation and drugs, the latter method in particular rendering the killing still more `medical.' The children's program was not included under the T4 `halt.'
Killing methods did not have to be changed: drugs and starvation, and not gas, had been employed from the beginning. The killing of children had been considerably less visible, taking place as it did on wards in smaller facilities without the telltale evidence of noxious smoke and odors that stemmed from large-scale gassing. The programs had been based more on presumed eugenic and scientific grounds than on direct economic ones (the children did not work and ate less) and had not created the degree of public controversy that adult killing had. If anything, the reporting methods for ostensible abnormalities became more systematic. Research efforts, mostly post-mortem studies, also became more systematic, as sometimes happened in adult `wild euthanasia.'
Not only did the regime remain closely involved, but the greater part of the killing of children took place after the official ending of the `euthanasia' project. What did become more `wild' was the method of deciding which children should be killed. Now even the pretense of review boards of `expert opinion' was abandoned: any child considered in some way impaired, and sent though the administrative system to any of the `special pediatric units' of the original project, was still fair game. Beyond that, institutional doctors could proceed according to their own inclinations.
Adult `wild euthanasia' involved more radical changes for psychiatrists. No longer operators of gas chambers, they returned to the familiar terrain of syringes, oral medications, and dietary prescriptions of achieving the same end. From the regime's medical bureaucracy came the continuing message that mental patients were `useless eaters,' burdens on the state and its war effort, `life unworthy of life.' Permission to kill was clear enough, even if a little indirect. As one psychiatrist later testified, `In conversation with other participants in the program I learned that there would be no fuss if some physician or other in an institution stood ready to kill a patient by injection or overdose, if he was convinced that the patient's extinction was desirable.' And there was a partial merger of child and adult `euthanasia' programs as the age limit of the children's program was raised to sixteen years: `to some extent this expansion was to offer a substitute for the canceled program.'<2> There were, in fact, documented cases of patients of about that age who had managed to survive the official end of the adult `euthanasia' program only to be fatally reclassified as a child.<3><52> Hefelmann testimony, 6-15 September 1960, Heyde Trial, pp. 681-82. See also p. 680<1> Ernst Klee, "Euthansie" im NS-Staat: Die "Vernichtung lebensunwerten Lebens" (Frankfurt/M: S. Fischer, 1983, p. 440)<2> Friedrich Mennecke, quoted in Alexander Mitscherlich and Fred Mielke, "Doctors of Infamy: The Story of the Nazi Medical Crimes" (New York:n Henry Schuman, 1949) p. 116
Extracted from THE NAZI DOCTORS: Medical Killing and the Psychology of Genocide.Lifton, Robert Jay, London: Papermac, 1986 (Reprinted 1990)__pp.95-97
Saturday, 21 March 2009
I take 40mg of Paroxetine (Seroxat) per day & 50mg Tramadol - these drugs interact causing Serotonin syndrome !!
I take 40mg of Paroxetine (Seroxat) per day for depression. 50mg Tramadol per day for my arthritis. 75mg Dothiepan just before bedtime (another anti depressant though my GP says it should help me get a better sleep) 15mg Zoton (Reflux Osophugus)
Clinically Significant Drug Interactions - March 15, 2000 - American Academy of Family Physicians
Clinically Significant Drug Interactions - March 15, 2000 - American Academy of Family Physicians: "Tramadol
Tramadol (Ultram) is a centrally acting analgesic with two modes of action: weak binding to the µ-opiate receptor and inhibition of norepinephrine and serotonin reuptake. Reports of serotonin syndrome in association with tramadol and SSRI coadministration appear in the literature.27 Because depression and chronic pain syndromes frequently coexist, physicians are likely to encounter situations in which this combination is used"
Tramadol (Ultram) is a centrally acting analgesic with two modes of action: weak binding to the µ-opiate receptor and inhibition of norepinephrine and serotonin reuptake. Reports of serotonin syndrome in association with tramadol and SSRI coadministration appear in the literature.27 Because depression and chronic pain syndromes frequently coexist, physicians are likely to encounter situations in which this combination is used"
Friday, 20 March 2009
Sucker Fiddaman taken for a ride by the corrupt MHRA
I have met with both Sarah and Kent at a meeting last September where the issue of SSRi withdrawal was discussed. As yet, nothing has materialised from that meeting with regard to informing doctors, the BNF and to arrange a meeting with Dr. David Healy. I know these things take time but as each hour passes more and more consumers of these products are going through needless suffering. I am in no position to speed up the process, that, ladies and gentlemen, lays solely on you.
http://fiddaman.blogspot.com/2009/03/email-to-mhra-regarding-public.html
http://fiddaman.blogspot.com/2009/03/email-to-mhra-regarding-public.html
Thursday, 19 March 2009
"Is there anyone out there who can put me out of my misery"
TRIBUNAL - misc.legal Google Groups: "This company doctor agreed that I was disabled for the
purpose of the DDA, The Disability Discrimination Act 1995. My original
tribunal full hearing was due back in October but the respondent cancelled
it for November. They then cancelled it until January. It has now been
cancelled again. On top of all this I have been verbally bullied by senior
management, had little, or no union backing. My wife has had a complete
nervous breakdown and I, myself, now need to attend counselling for my
severe depression. I did get in touch with a law firm but unfortunately they
were closed down by the Law Society. My papers are now with a Law Advisor
who assures me that everything will be fine. I am now at my wits end, and
have i the past attempted suicide to rid me of this pain.
Is there anyone out there who can put me out of my misery?
Please email me
Bob"
"I would be happy to do office work or other lighter duties" - so why is Fiddaman sponging off the state
MY CASE IN THE PRESS(Long) - alt.rock-n-roll.acdc | Google Groups: "Although I am not able to do heavy manual work, I would be happy to do
office work or other lighter duties.'"
office work or other lighter duties.'"
Derek Scott said - "the seroxat.org group website is a committee website set up by Mark Harvey of Hugh James Solicitors"
Name: Derek (80.195.69.176, 80.195.69.176)
Subject: Re: Re: Seroxat User Group
Mon, Mar 10 2003 at 10:14 am
[ Email Msg | Invite ]
Message:
Debs the seroxat.org group website is a committee website set up by Mark Harvey of Hugh James Solicitors, whereas the http://web.archive.org/web/20040120103524/http://www.seroxatusergroup.co.uk/ is there to support actual users who have difficulty getting off the drug. I dont know anything about the other 2 yahoo groups.
Derek.
source - http://web.archive.org/web/20040120103524/forum.onecenter.com/cgi-bin/forum/forum.cgi?c=msg&fid=seroxat&mid=283
Subject: Re: Re: Seroxat User Group
Mon, Mar 10 2003 at 10:14 am
[ Email Msg | Invite ]
Message:
Debs the seroxat.org group website is a committee website set up by Mark Harvey of Hugh James Solicitors, whereas the http://web.archive.org/web/20040120103524/http://www.seroxatusergroup.co.uk/ is there to support actual users who have difficulty getting off the drug. I dont know anything about the other 2 yahoo groups.
Derek.
source - http://web.archive.org/web/20040120103524/forum.onecenter.com/cgi-bin/forum/forum.cgi?c=msg&fid=seroxat&mid=283
Derek Scott said - "Seroxat does help" & accepts that "all antidepressants cause some form of withdrawal"
http://web.archive.org/web/20030110084126/forum.onecenter.com/cgi-bin/forum/forum.cgi?c=msg&fid=seroxat&mid=88
Name: Derek
Subject: Re: Seroxat
Tue, Dec 10 2002 at 12:18 pm
[ Email Msg | Invite ]
Message:
Seroxat is very addictive, with serious side effects and withdrawal symptoms. However all antidepressants cause some form of withdrawal, saying this though Seroxat is the #1 drug in the UK in terms of causing severe withdrawal symptoms, and is also #1 on the World Health Organization hit list of drugs that cause withdrawal, and therefore dependence. Seroxat does help, just be sure you know what you are letting yourself in for in the long term.
Derek.
2001 sees Fiddaman noticing class action lawsuit - the start of his latest scam !!
class action lawsuit? - alt.uk.law | Google Groups: "fiddy View profile Translated (View Original)
More options 5 Sep 2001, 05:19
Newsgroups: alt.uk.law
From: 'fiddy'
Date: Wed, 05 Sep 2001 05:20:01 GMT
Local: Wed 5 Sep 2001 05:20
Subject: class action lawsuit?
Reply to author | Forward | Print | Individual message | Show original | Report this message | Find messages by this author
There has been a recent class action lawsuit in the States against the
makers of a drug called Paroxetine.
I have been on this drug for the past two and a half years and am now
hooked. Any phased withdrawal has me going through all the symptomatic
problems that this dug professes WILL NOT occur.
What is a class action Lawsuit?
How do I sue the Makers of this drug Many Thanks
Bob
Birmingham
UK"
More options 5 Sep 2001, 05:19
Newsgroups: alt.uk.law
From: 'fiddy'
Date: Wed, 05 Sep 2001 05:20:01 GMT
Local: Wed 5 Sep 2001 05:20
Subject: class action lawsuit?
Reply to author | Forward | Print | Individual message | Show original | Report this message | Find messages by this author
There has been a recent class action lawsuit in the States against the
makers of a drug called Paroxetine.
I have been on this drug for the past two and a half years and am now
hooked. Any phased withdrawal has me going through all the symptomatic
problems that this dug professes WILL NOT occur.
What is a class action Lawsuit?
How do I sue the Makers of this drug Many Thanks
Bob
Birmingham
UK"
Wednesday, 18 March 2009
UK Peeps - alt.rock-n-roll.acdc | Google Groups
UK Peeps - alt.rock-n-roll.acdc | Google Groups: "Apologies first for this totally off topic post.
Some of you know, I have been busy of late with an up and coming lawsuit
against a particular pharmaceutrical company and more importantly the
govermental body that grants licenses to them.
You can help me by downloading a petition and obtaining as many signatures
as you possibly can.
We have a deadline of one month to get 1000 plus signatures to present to
the House of Commons.
Form can be downloaded here
http://fiddaman.blogspot.com/2006/04/seroxat-petition.html
Thanks for your time
Fid"
Some of you know, I have been busy of late with an up and coming lawsuit
against a particular pharmaceutrical company and more importantly the
govermental body that grants licenses to them.
You can help me by downloading a petition and obtaining as many signatures
as you possibly can.
We have a deadline of one month to get 1000 plus signatures to present to
the House of Commons.
Form can be downloaded here
http://fiddaman.blogspot.com/2006/04/seroxat-petition.html
Thanks for your time
Fid"
OT: American BOD invades Scotland ... - alt.rock-n-roll.acdc | Google Groups
OT: American BOD invades Scotland ... - alt.rock-n-roll.acdc | Google Groups: "Damn. I'll be in Glasgow on the 20th July to see the 'new' Big Country at
the Glasgow Garage then Aberdeen Lemon Tree the night after. Enjoy Kirrie
and pay a visit to Chick & Isa's former shop, they will tell you where it is
at the museum.
Fid"
the Glasgow Garage then Aberdeen Lemon Tree the night after. Enjoy Kirrie
and pay a visit to Chick & Isa's former shop, they will tell you where it is
at the museum.
Fid"
Benefits thief & fraudster Bob Fiddaman 2007 tour of Scotland
OT: American BOD invades Scotland ... - alt.rock-n-roll.acdc | Google Groups: "I'll be in Edinburgh (Dunfemline) on Wed 18th July, Glasgow on the 20th,
Aberdeen on the 21st and Edinburgh (Dunfemline) from the 22 to 23rd.
Lemme know if you are around these days - Be good to hook up with Capper,
Tom and Cam too
Fid
--
Seroxat Sufferers
http://fiddaman.blogspot.com"
http://groups.google.co.uk/group/alt.rock-n-roll.acdc/browse_thread/thread/c5a3c1182aaa0a3f/9a33361f71384062?hl=en&ie=UTF-8&q=fiddy+seroxat
Aberdeen on the 21st and Edinburgh (Dunfemline) from the 22 to 23rd.
Lemme know if you are around these days - Be good to hook up with Capper,
Tom and Cam too
Fid
--
Seroxat Sufferers
http://fiddaman.blogspot.com"
http://groups.google.co.uk/group/alt.rock-n-roll.acdc/browse_thread/thread/c5a3c1182aaa0a3f/9a33361f71384062?hl=en&ie=UTF-8&q=fiddy+seroxat
Tuesday, 17 March 2009
Mark Harvey's trial by press release continues
Birdsedge woman sues drug firm for £50,000 - Huddersfield Examiner: "Birdsedge woman sues drug firm for £50,000
Mar 14 2009 By Katie Grant
12next »
A WOMAN is claiming damages of up to £50,000 for personal injuries she suffered from using an antidepressant.
Solicitors on behalf of Linda Forster, of Park Lane, Birdsedge, have served a High Court Writ against drugs company GlaxoSmithKline UK Ltd (GSK)
It is claimed Forster suffered as a result of using Seroxat, an antidepressant which is manufactured by the company."
http://www.examiner.co.uk/news/local-west-yorkshire-news/2009/03/14/birdsedge-woman-sues-drug-firm-for-50-000-86081-23140775/
Mar 14 2009 By Katie Grant
12next »
A WOMAN is claiming damages of up to £50,000 for personal injuries she suffered from using an antidepressant.
Solicitors on behalf of Linda Forster, of Park Lane, Birdsedge, have served a High Court Writ against drugs company GlaxoSmithKline UK Ltd (GSK)
It is claimed Forster suffered as a result of using Seroxat, an antidepressant which is manufactured by the company."
http://www.examiner.co.uk/news/local-west-yorkshire-news/2009/03/14/birdsedge-woman-sues-drug-firm-for-50-000-86081-23140775/
Jailed student's drunken rage caused by Seroxat, claims doctor - but Judge did not agree !!
Jailed student's drunken rage caused by Seroxat, claims doctor
Oct 23 2002 The Western Mail
A STUDENT jailed for crashing his car through the doors of a North Wales psychiatric unit could have been acting under the influence of side-effects of a controversial anti-depressant.
Dr David Healy, a leading expert on the drug Seroxat, will give evidence about Shane Cooke's condition as part of an appeal against his two-and-a-half-year sentence.
Lawyers have been instructed to proceed with an appeal and Dr Healy, who has given evidence in the US about the effects of Seroxat, has been engaged to prepare a report on Shane's condition.
Dr Healy, director of the North medicine, believes the evidence so far suggests the drug could have played a part in what happened to Shane.
Seroxat has been linked to both suicidal and homicidal tendencies, including the case of Wyoming grandfather Donald Schell who shot himself, his wife, his daughter and grand-daughter dead just two days after he started taking Seroxat to treat depression.
South Wales law firm Hugh James is now acting on behalf of about 3,000 people across the UK who have experienced unwanted side-effects from Seroxat, known in the US as Paxil.
Shane Cooke's foster parents said bull" during three violent outbursts after he was prescribed Seroxat in March. His character changed so much Brian and Mary Hennesey no longer recognised him, they said.
"He was a totally different person. The least upset would bring on a major outburst," Mrs Hennesey said.
A judge at Caernarfon Crown Court jailed the health and social care student, of Meadow Villas, Greenfield, near Holywell, on Monday, saying he was in a drunken rage when he crashed a car through the doors into the foyer of Ysbyty Glan Clwyd on June 2.But Mr and Mrs Hennesey believe Shane did not understand what was help and "completely lost it" when he was not allowed into the psychiatric unit. They are convinced that - while he had taken alcohol - the main reason for his uncontrollable rage was the effect of Seroxat.
Mr and Mrs Hennesey, who have cared for Shane since he was two, said alcohol was not a factor in the two other violent outbursts. Mrs Hennesey, a special needs teacher in Holywell, said Shane had heard voices and saw visions of his mother when he was first prescribed the drug.
Seroxat manufacturer Glaxo-SmithKline denies the anti-depressant causes addiction or suicidal
Oct 23 2002 The Western Mail
A STUDENT jailed for crashing his car through the doors of a North Wales psychiatric unit could have been acting under the influence of side-effects of a controversial anti-depressant.
Dr David Healy, a leading expert on the drug Seroxat, will give evidence about Shane Cooke's condition as part of an appeal against his two-and-a-half-year sentence.
Lawyers have been instructed to proceed with an appeal and Dr Healy, who has given evidence in the US about the effects of Seroxat, has been engaged to prepare a report on Shane's condition.
Dr Healy, director of the North medicine, believes the evidence so far suggests the drug could have played a part in what happened to Shane.
Seroxat has been linked to both suicidal and homicidal tendencies, including the case of Wyoming grandfather Donald Schell who shot himself, his wife, his daughter and grand-daughter dead just two days after he started taking Seroxat to treat depression.
South Wales law firm Hugh James is now acting on behalf of about 3,000 people across the UK who have experienced unwanted side-effects from Seroxat, known in the US as Paxil.
Shane Cooke's foster parents said bull" during three violent outbursts after he was prescribed Seroxat in March. His character changed so much Brian and Mary Hennesey no longer recognised him, they said.
"He was a totally different person. The least upset would bring on a major outburst," Mrs Hennesey said.
A judge at Caernarfon Crown Court jailed the health and social care student, of Meadow Villas, Greenfield, near Holywell, on Monday, saying he was in a drunken rage when he crashed a car through the doors into the foyer of Ysbyty Glan Clwyd on June 2.But Mr and Mrs Hennesey believe Shane did not understand what was help and "completely lost it" when he was not allowed into the psychiatric unit. They are convinced that - while he had taken alcohol - the main reason for his uncontrollable rage was the effect of Seroxat.
Mr and Mrs Hennesey, who have cared for Shane since he was two, said alcohol was not a factor in the two other violent outbursts. Mrs Hennesey, a special needs teacher in Holywell, said Shane had heard voices and saw visions of his mother when he was first prescribed the drug.
Seroxat manufacturer Glaxo-SmithKline denies the anti-depressant causes addiction or suicidal
Scientology promoting Bob Fiddaman's blog
A Psychiatric Victim’s Blog « Psychiatric News: "A Psychiatric Victim’s Blog
The following link is worth looking at. Fiddy is an actual victim of antidepressants and puts out a good Blog.
http://fiddaman.blogspot.com/2007/03/suicide-attempts-in-clinical-trials.html"
The following link is worth looking at. Fiddy is an actual victim of antidepressants and puts out a good Blog.
http://fiddaman.blogspot.com/2007/03/suicide-attempts-in-clinical-trials.html"
Fiddaman declared fit for some form of work by Incapacity Benefit office - decides to continue malingering by getting signed off as Depressed
More options 6 Mar 2000, 08:00
Newsgroups: alt.support.arthritis
From: "ballbreaker375"
Date: 2000/03/06
Subject: Real Problem
Reply to author | Forward | Print | Individual message | Show original | Report this message | Find messages by this author
Dear Newsgroup Members,
I have been on Incapacity Benefit for the past three years due to developing
Osteoarthritis in both hips. I am currently on the Long Term Absence
Register at work.
I have applied for Ill Health Early Retirement but have been denied this
Because my company doctor states that I have a condition that can be
Rectified with an operation.
When my employer's were offering Voluntary Redundancy Packages I asked if I
Could apply, I was told that I could not apply as I was on the Long Term
Absence Register
I was taken off Incapacity Benefit after visiting my local benefits office
For an assessment. It was in their opinion that I could do a 'form' of work.
My GP then signed me unfit for work due to suffering from depression.
I have an ongoing case in the tribunals against my employers and I recently
Saw an independant Physiotherapist who informs me that I have only 10%
Movement in my right hip. Does this qualify me for Disability Living
Allowance?
I would be grateful for any feedback on these issues.
Thanks in advance
Bob
ballbreaker...@netscapeonline.co.UK
http://groups.google.co.UK/group/alt.support.arthritis/browse_thread/thread/f89c58f3ef911bd7/172b114405404c9f?hl=en-GB&ie=UTF-8&q=fiddaman+donna
Newsgroups: alt.support.arthritis
From: "ballbreaker375"
Date: 2000/03/06
Subject: Real Problem
Reply to author | Forward | Print | Individual message | Show original | Report this message | Find messages by this author
Dear Newsgroup Members,
I have been on Incapacity Benefit for the past three years due to developing
Osteoarthritis in both hips. I am currently on the Long Term Absence
Register at work.
I have applied for Ill Health Early Retirement but have been denied this
Because my company doctor states that I have a condition that can be
Rectified with an operation.
When my employer's were offering Voluntary Redundancy Packages I asked if I
Could apply, I was told that I could not apply as I was on the Long Term
Absence Register
I was taken off Incapacity Benefit after visiting my local benefits office
For an assessment. It was in their opinion that I could do a 'form' of work.
My GP then signed me unfit for work due to suffering from depression.
I have an ongoing case in the tribunals against my employers and I recently
Saw an independant Physiotherapist who informs me that I have only 10%
Movement in my right hip. Does this qualify me for Disability Living
Allowance?
I would be grateful for any feedback on these issues.
Thanks in advance
Bob
ballbreaker...@netscapeonline.co.UK
http://groups.google.co.UK/group/alt.support.arthritis/browse_thread/thread/f89c58f3ef911bd7/172b114405404c9f?hl=en-GB&ie=UTF-8&q=fiddaman+donna
Monday, 16 March 2009
"bleak future ahead I just wondered if I have a chance of claiming DLA" - lying benefit cheat in Bangkok
OK, I use a CPAP Machine to 'aid' me when I'm sleeping. I average about 4
hours sleep per night!!!!!
I take 40mg of Paroxetine (Seroxat) per day for depression.
50mg Tramadol per day for my arthritis.
75mg Dothiepan just before bedtime (another anti depressant though my GP
says it should help me get a better sleep)
15mg Zoton (Reflux Osophugus)
I sleep for about an hour in the day and can be a moody bastard when I wanna
be. Sudden loud noises really grind my teeth, though I think this is due to
the Paroxetine, a drug that I have on numerous occasions tried to wean
myself off by decreasing the dose. Did a search on Paroxetine on the nest
and found that there are many people suffering withdrawal symptoms:(
With one suicide attempt to my name and a bleak future ahead I just wondered
if I have a chance of claiming DLA?
Bob, Birmingham, UK
---
Outgoing mail is certified Virus Free.
BOB 'THE CHAINSAW' FIDDAMAN
Checked by AVG anti-virus system (http://www.grisoft.com).
Version: 6.0.365 / Virus Database: 202 - Release Date: 24/05/2002
strange Bob Fiddaman says (Seroxat) "helps some people"
What's better than Aropax or Prozac? :: WHO backed up alternative treatment for depression :: Acupuncture: "Yes, it helps some people
Bob Fiddaman also said -
Hi Nathan,
I can agree with you to a certain extent regarding whether they work. They [Seroxat] worked for me… if masking the illness and losing all empathy is working.
http://209.85.229.132/search?q=cache:62zY663SNEcJ:www.pharmalot.com/2008/06/grassley-probes-paxil-suicide-risks/+mark+harvey+fiddaman&hl=en&ct=clnk&cd=7&gl=uk
48 out of 334 switched to other ssri or venlafaxine experienced suicidal event
In the study, 334 adolescent patients who had not responded to a selective serotonin reuptake inhibitor (SSRI) were switched to a different SSRI or to venlafaxine, with or without cognitive-behavioral therapy. Forty-eight patients experienced a suicidal event-suicidal ideation (new or worsening), a suicidal threat or a suicide attempt. The median time from a suicidal threat to a suicidal event was three weeks. In the AJP article, lead author David Brent, M.D., and colleagues recommend careful monitoring of more severely depressed adolescent patients who have high levels of suicidal thoughts or family conflict.
http://www.medicalnewstoday.com/articles/139601.php
Risk Factors For Suicidal Events Found Among Adolescents With Treatment-Resistant Depression
Main Category: Depression
Also Included In: Psychology / Psychiatry
Article Date: 19 Feb 2009 - 4:00 PST
email to a friend printer friendly view / write opinions rate article
http://download.macromedia.com/pub/shockwave/cabs/flash/swflash.cab#version=6,0,0,0" classid=clsid:D27CDB6E-AE6D-11cf-96B8-444553540000 width=300 height=250>
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Family conflict, drug or alcohol use and pre-existing suicidal thoughts were the strongest predictors of suicidal events among adolescents whose depression treatment was changed after a lack of response to a previous medication.
The findings were reported today in the article "Predictors of Spontaneous and Systematically Assessed Suicidal Adverse Events in the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) Study," at AJP in Advance, the online advance edition of The American Journal of Psychiatry (AJP), the official journal of the American Psychiatric Association.
In the study, 334 adolescent patients who had not responded to a selective serotonin reuptake inhibitor (SSRI) were switched to a different SSRI or to venlafaxine, with or without cognitive-behavioral therapy. Forty-eight patients experienced a suicidal event-suicidal ideation (new or worsening), a suicidal threat or a suicide attempt. The median time from a suicidal threat to a suicidal event was three weeks. In the AJP article, lead author David Brent, M.D., and colleagues recommend careful monitoring of more severely depressed adolescent patients who have high levels of suicidal thoughts or family conflict.
Treatments that target family conflict and emotion regulation early may help reduce suicidal events. Likewise, since the predictors of suicidal events also predict poor treatment response, targeting family conflict, suicidal ideation and drug use may hasten response and help to reduce the incidence of these events. TORDIA is sponsored by the National Institute of Mental Health. Any other funding the authors may have received is disclosed in the article itself.
The American Journal of Psychiatry is the official journal of the American Psychiatric Association. Statements in this press release or the articles in the Journal are not official policy statements of the American Psychiatric Association.
About the American Psychiatric Association
The American Psychiatric Association is a national medical specialty society whose more than 38,000 physician members specialize in diagnosis, treatment, prevention and research of mental illnesses, including substance use disorders. Visit the APA at http://www.psych.org and http://www.HealthyMinds.org.
American Psychiatric Association
http://www.network54.com/Forum/281849/message/1237128370/Risk+Factors+For+Suicidal+Events+Found+Among+Adolescents+With+Treatment-Resistant+Depressi
http://www.medicalnewstoday.com/articles/139601.php
Risk Factors For Suicidal Events Found Among Adolescents With Treatment-Resistant Depression
Main Category: Depression
Also Included In: Psychology / Psychiatry
Article Date: 19 Feb 2009 - 4:00 PST
email to a friend printer friendly view / write opinions rate article
http://download.macromedia.com/pub/shockwave/cabs/flash/swflash.cab#version=6,0,0,0" classid=clsid:D27CDB6E-AE6D-11cf-96B8-444553540000 width=300 height=250>
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Current Article Ratings:
Patient / Public: 4 (1 votes)
Health Professional:
Article Opinions: 1 posts
Find other articles on: "venlafaxine"
Family conflict, drug or alcohol use and pre-existing suicidal thoughts were the strongest predictors of suicidal events among adolescents whose depression treatment was changed after a lack of response to a previous medication.
The findings were reported today in the article "Predictors of Spontaneous and Systematically Assessed Suicidal Adverse Events in the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) Study," at AJP in Advance, the online advance edition of The American Journal of Psychiatry (AJP), the official journal of the American Psychiatric Association.
In the study, 334 adolescent patients who had not responded to a selective serotonin reuptake inhibitor (SSRI) were switched to a different SSRI or to venlafaxine, with or without cognitive-behavioral therapy. Forty-eight patients experienced a suicidal event-suicidal ideation (new or worsening), a suicidal threat or a suicide attempt. The median time from a suicidal threat to a suicidal event was three weeks. In the AJP article, lead author David Brent, M.D., and colleagues recommend careful monitoring of more severely depressed adolescent patients who have high levels of suicidal thoughts or family conflict.
Treatments that target family conflict and emotion regulation early may help reduce suicidal events. Likewise, since the predictors of suicidal events also predict poor treatment response, targeting family conflict, suicidal ideation and drug use may hasten response and help to reduce the incidence of these events. TORDIA is sponsored by the National Institute of Mental Health. Any other funding the authors may have received is disclosed in the article itself.
The American Journal of Psychiatry is the official journal of the American Psychiatric Association. Statements in this press release or the articles in the Journal are not official policy statements of the American Psychiatric Association.
About the American Psychiatric Association
The American Psychiatric Association is a national medical specialty society whose more than 38,000 physician members specialize in diagnosis, treatment, prevention and research of mental illnesses, including substance use disorders. Visit the APA at http://www.psych.org and http://www.HealthyMinds.org.
American Psychiatric Association
http://www.network54.com/Forum/281849/message/1237128370/Risk+Factors+For+Suicidal+Events+Found+Among+Adolescents+With+Treatment-Resistant+Depressi
Promoting Janice Simmons / SeroxatUSERgroup on Scientology news group !!
Psych Drugs Are Addictive - alt.religion.scientology | Google Groups: "From Hunts Post. 'Prime Minister Gordon Brown is to meet a woman from
Huntingdon, who has been campaigning for five years to highlight potential
problems with anti-depressants.
Janice Simmons set up the Seroxat User Group in 2002 after discovering that her
second husband Jon was addicted to the drug.
Since then thousands of people have contacted her website and the group has
provided information to people from all over the world"
Huntingdon, who has been campaigning for five years to highlight potential
problems with anti-depressants.
Janice Simmons set up the Seroxat User Group in 2002 after discovering that her
second husband Jon was addicted to the drug.
Since then thousands of people have contacted her website and the group has
provided information to people from all over the world"
advice for coming off anti-depressants, can be found at www.seroxatusergroup.org.uk - can't Fiddaman read?
Seroxat probe sparks web hits
http://www.huntspost.co.uk/content/hunts/news/story.aspx?brand=HPTOnline&category=News&tBrand=cambs24&tCategory=NewsHPT&itemid=WEED07%20Feb%202007%2011%3A20%3A56%3A610
Mrs Simmons told The Hunts Post: "This documentary is the recognition of a problem I have been fighting for over the past four years.
"The most dangerous time for people taking anti-depressants is when you first go on them, when the dose is raised and when you try to come off them.
"We need to get the word out that these drugs can be dangerous for adults, too. Medicine is applied too generally and people react differently to it.
"We want people to write to their GPs asking for action. People have lost their lives, their families, their jobs. So many people have lost so much because of a little tablet."
INFORMATION: The Seroxat User Group's website, which includes advice for coming off anti-depressants, can be found at www.seroxatusergroup.org.uk
Bob Fiddaman's other antidepressant killed 127 times more than GSK's Seroxat
http://ukpmc.ac.uk/articlerender.cgi?artid=480175&rendertype=table&id=TN0x8a59168.0x9a59c30
drug name - no scripts - no deaths
Dothiepin - 26210 - 1398
Paroxetine - 15031 - 11
drug name - no scripts - no deaths
Dothiepin - 26210 - 1398
Paroxetine - 15031 - 11
Sunday, 15 March 2009
of the SSRI/SNRI currently in use Seroxat is the least likely to kill you
drug name --- no scripts(thousands) --- no deaths --- Deaths/million scripts
Serotoninergic drugs: 47329 ---77 ---1.6 (1.3 to 2.0)
Venlafaxine x20022570 34 13.2 (9.2 to 18.5)
Fluvoxamine x2002x2002660 2 3.0 (0.3 to 10.9)
Citalopram x20022603 5 1.9 (0.6 to 4.5)
Sertraline x20025964 7 1.2 (0.5 to 2.4)
Fluoxetine 19926 18 0.9 (0.5 to 1.4)
Paroxetine 15031 11 0.7 (0.4 to 1.3)
Nefazodone x2002x2002576 0 0 (0 to 6.4)
http://ukpmc.ac.uk/articlerender.cgi?artid=480175&rendertype=table&id=TN0x8a59168.0x9a59c30
Serotoninergic drugs: 47329 ---77 ---1.6 (1.3 to 2.0)
Venlafaxine x20022570 34 13.2 (9.2 to 18.5)
Fluvoxamine x2002x2002660 2 3.0 (0.3 to 10.9)
Citalopram x20022603 5 1.9 (0.6 to 4.5)
Sertraline x20025964 7 1.2 (0.5 to 2.4)
Fluoxetine 19926 18 0.9 (0.5 to 1.4)
Paroxetine 15031 11 0.7 (0.4 to 1.3)
Nefazodone x2002x2002576 0 0 (0 to 6.4)
http://ukpmc.ac.uk/articlerender.cgi?artid=480175&rendertype=table&id=TN0x8a59168.0x9a59c30
Fiddaman's other antidepressant kills 1398 whereas Seroxat only killed 11
So where is the outcry?
So where is the outcry?
(from) Fatal toxicity index (deaths per million prescriptions) for antidepressants ranked within British National Formulary classes
example
http://ukpmc.ac.uk/articlerender.cgi?artid=480175&rendertype=table&id=TN0x8a59168.0x9a59c30
drug name - no scripts - no deaths
Dothiepin - 26210 - 1398
Paroxetine - 15031 - 11
http://ukpmc.ac.uk/articlerender.cgi?artid=480175&rendertype=table&id=TN0x8a59168.0x9a59c30
drug name - no scripts - no deaths
Dothiepin - 26210 - 1398
Paroxetine - 15031 - 11
Seroxat - Fraud in medical research
http://fiddaman.blogspot.com/2009/03/fraud-in-medical-research-gsk-bribes.html
This fraudster was taking a cocktail of Seroxat, Dothepin & tramadol
Saturday, 14 March 2009
(former) Trade union worker describes Fiddaman as a lazy shit
http://groups.google.co.uk/group/alt.rock-n-roll.acdc/browse_thread/thread/54c1b222a78b9c44/fba1aa40dbda1143?hl=en-GB&ie=UTF-8&q=fiddy+ego&pli=1
17 Jun 2001 20:49 capn plectrym said -
Dave, there is no need for you to explain. I basically stopped reading
the posts regarding his work/life problems long ago. The only reason
why I checked this thread out was the large number of responses. I was
honestly not surprised someone finally got tired of it all.
I have worked in an union for over 7 years and finally got out of it,
because of shit like Bob, or Fiddy, or poetboy, or whatever nickname
he gives himself, is doing. The lazy fucks I worked with looked for
more ways to make money without working than actually trying to make
themselves more valuable to the company. You wouldn't believe some of
the ailments that they would get and try to milk the company. I
finally got tired enough of it to get a non-union job, I make more
money now, and I don't have to listen to a shit load of whining.
In the NG, there are people here that will share certain things in
their lives, usually if it pertains to AC/DC. I have never seen Dave
talk about alcoholism that solicited a response from the NG. The
marital issues with Top only surfaced when Top was gone for a long
time and people were asking where he was. He didnt make posts like
TOPS MARRIAGE IS GOING DOWN THE SHITTER, EVERYONE PLEASE SUFFER WITH
ME.
I responded to Tops that I hope all goes well, and that was it. We
didnt hear anything about it until someone in the NG mentioned it
again, which was followed by an update from Top.
What Im getting at Bob, is that you have made your point, we have made
ours, we basically stated that we really are done hearing about it,
yet you keep going, and going, and going annnnnnnnnnnnd going.
Now you have burned bridges with people that seemed to like you and
did care how things went with you.
Now, Bob, please move on with your life.
17 Jun 2001 20:49 capn plectrym said -
Dave, there is no need for you to explain. I basically stopped reading
the posts regarding his work/life problems long ago. The only reason
why I checked this thread out was the large number of responses. I was
honestly not surprised someone finally got tired of it all.
I have worked in an union for over 7 years and finally got out of it,
because of shit like Bob, or Fiddy, or poetboy, or whatever nickname
he gives himself, is doing. The lazy fucks I worked with looked for
more ways to make money without working than actually trying to make
themselves more valuable to the company. You wouldn't believe some of
the ailments that they would get and try to milk the company. I
finally got tired enough of it to get a non-union job, I make more
money now, and I don't have to listen to a shit load of whining.
In the NG, there are people here that will share certain things in
their lives, usually if it pertains to AC/DC. I have never seen Dave
talk about alcoholism that solicited a response from the NG. The
marital issues with Top only surfaced when Top was gone for a long
time and people were asking where he was. He didnt make posts like
TOPS MARRIAGE IS GOING DOWN THE SHITTER, EVERYONE PLEASE SUFFER WITH
ME.
I responded to Tops that I hope all goes well, and that was it. We
didnt hear anything about it until someone in the NG mentioned it
again, which was followed by an update from Top.
What Im getting at Bob, is that you have made your point, we have made
ours, we basically stated that we really are done hearing about it,
yet you keep going, and going, and going annnnnnnnnnnnd going.
Now you have burned bridges with people that seemed to like you and
did care how things went with you.
Now, Bob, please move on with your life.
The "corrupt regulator" meets the "benefits thief" whilst 95% of the antidepressant issue goes unregulated
Prescription items dispensed (PXS) times 1000
Total for chemical entity : Citalopram Hydrobromide 7,830.7
Total for chemical entity : Fluoxetine Hydrochloride 5,045.7
Total for chemical entity : Venlafaxine Hydrochloride 2,274.7
Total for chemical entity : Sertraline Hydrochloride 2,032.8
Total for chemical entity : Paroxetine Hydrochloride 1,765.9
Total for chemical entity : Escitalopram 1,373.9
Total for chemical entity : Duloxetine Hydrochloride 267.3
Total for chemical entity : Fluvoxamine Maleate 29.9
http://www.ic.nhs.uk/webfiles/publications/PCA%20publication/PCA%202007%20complete%20V2.pdf
Total for BNF : 4 . 3 Antidepressant Drugs 33,839.6
Friday, 13 March 2009
Fiddaman's meeting with MHRA - clearly his intent was to discuss only Seroxat - Fiddaman you are a cunt !
Hi Lara.
I think it best if I introduce myself properly.
http://www.antidepressantawareness.com/forums/archive/index.php/t-291.html
I have been campaigning against Seroxat for some four years now, the last two saw me launch my blog 'Seroxat Sufferers'. I know thousands of people who have suffered at the hands of Seroxat, maybe not personally, but via email and on various forums.
I have also been trying to secure a meetuing with the UK Medicines Regulator [MHRA] for some time to discuss the issue of withdrawal regarding Seroxat... I now have that meeting and amongst other things will be pushing for a program for patients to withdraw. There is no current protocol for withdrawing from Seroxat other than 'You must taper slowly' - that is clearly NOT good enough.
The current Patient information leaflet [PIL] puts the onus on the doctor too much - Doctor's are not educated in Seroxat withdrawal because GlaxoSmithKline and the MHRA do not believe it exists. I and thousands of others know different!
I'm glad Australia is waking up to the withdrawal problem, Rebekah's book 'Dying For A Cure' will help bring about awareness.
Your regulator, the TGA, are about as useful as a chocolate kettle - they need to be hounded as I have hounded the MHRA.
It's been a rough journey. I've had threats from GSK lawyers, a smear campaign against my name and even some weirdo threatening to kill me. I guess that's the price one pays when they put their head on the block though.
There is a search facility at the top left hand corner of my blog. Type in 'Australia' and you will see some of the stories I have highlighted regarding Aropax.
Aussies have been kept in the dark for too long... somebody has just turned your light on :)
I think it best if I introduce myself properly.
http://www.antidepressantawareness.com/forums/archive/index.php/t-291.html
I have been campaigning against Seroxat for some four years now, the last two saw me launch my blog 'Seroxat Sufferers'. I know thousands of people who have suffered at the hands of Seroxat, maybe not personally, but via email and on various forums.
I have also been trying to secure a meetuing with the UK Medicines Regulator [MHRA] for some time to discuss the issue of withdrawal regarding Seroxat... I now have that meeting and amongst other things will be pushing for a program for patients to withdraw. There is no current protocol for withdrawing from Seroxat other than 'You must taper slowly' - that is clearly NOT good enough.
The current Patient information leaflet [PIL] puts the onus on the doctor too much - Doctor's are not educated in Seroxat withdrawal because GlaxoSmithKline and the MHRA do not believe it exists. I and thousands of others know different!
I'm glad Australia is waking up to the withdrawal problem, Rebekah's book 'Dying For A Cure' will help bring about awareness.
Your regulator, the TGA, are about as useful as a chocolate kettle - they need to be hounded as I have hounded the MHRA.
It's been a rough journey. I've had threats from GSK lawyers, a smear campaign against my name and even some weirdo threatening to kill me. I guess that's the price one pays when they put their head on the block though.
There is a search facility at the top left hand corner of my blog. Type in 'Australia' and you will see some of the stories I have highlighted regarding Aropax.
Aussies have been kept in the dark for too long... somebody has just turned your light on :)
Benefits thief Bob Fiddaman said "I have been to Australia twice for holidays, totally unrelated to my campaigning"
Calling Korean Workers - Glaxo Want to 'Help' You [Archive] - Antidepressant Awareness Online Forum: "fiddy6408-19-2008, 06:50 AM
The MHRA are the Medicines regulator here in the UK as the TGA are there in Australia. I have saved this past month for my train fare to London.
I have been to Australia twice for holidays, totally unrelated to my campaigning.
You may want to check out the following story too
http://fiddaman.blogspot.com/2007/09/small-victory-for-seroxat-sufferers.html"
The MHRA are the Medicines regulator here in the UK as the TGA are there in Australia. I have saved this past month for my train fare to London.
I have been to Australia twice for holidays, totally unrelated to my campaigning.
You may want to check out the following story too
http://fiddaman.blogspot.com/2007/09/small-victory-for-seroxat-sufferers.html"
Oh dear poor Bob forgot he went cold turkey from 22 mgs to zero - AGAINST ADVICE GIVEN TO HIM
Has anyone taken Paxil/Seroxat? - Hong Kong GeoExpat: "Google the words Fiddaman Seroxat. That will take you to my information page about Seroxat.
Whatever you do - DO NOT just stop taking it. You will have to come down slowly or you may suffer severe withdrawal effects. It took me 18 months to come down from 40mg to 22mg.
Your doctor should have known better but it is difficult for doctors because the manufacturer of Seroxat, GSK, have witheld the raw data regarding the Seroxat clinical trials.
Like I said, all will become clearer if you google the words SEROXAT FIDDAMAN.
Good luck
Fiddy"
Whatever you do - DO NOT just stop taking it. You will have to come down slowly or you may suffer severe withdrawal effects. It took me 18 months to come down from 40mg to 22mg.
Your doctor should have known better but it is difficult for doctors because the manufacturer of Seroxat, GSK, have witheld the raw data regarding the Seroxat clinical trials.
Like I said, all will become clearer if you google the words SEROXAT FIDDAMAN.
Good luck
Fiddy"
MHRA - FOI 09/086 - RE: Antidepressant suicide warning (on or about Aug 2000)
FOI 09/086 - RE: Antidepressant suicide warning (on or about Aug 2000)
Our Ref: FOI 09/086
Dear Mr Bryce,
RE: REQUEST UNDER THE FREEDOM OF INFORMATION ACT 2000
Thank you for your enquiry which we received on 12th March 2009.
I confirm that your request is being handled under the Freedom of Information Act and you should receive a reply within 20 working days from our date of receipt.
If you need to contact us again about this request, please quote the reference number above.
Yours Sincerely
Central Enquiry Point
Information Centre
MHRA
Market Towers
London SW8 5NQ
Tel: +44 (0)207084 2000
FAX: +44 (0)207084 2353
source - http://groups.yahoo.com/group/uksurvivors/message/43157
Our Ref: FOI 09/086
Dear Mr Bryce,
RE: REQUEST UNDER THE FREEDOM OF INFORMATION ACT 2000
Thank you for your enquiry which we received on 12th March 2009.
I confirm that your request is being handled under the Freedom of Information Act and you should receive a reply within 20 working days from our date of receipt.
If you need to contact us again about this request, please quote the reference number above.
Yours Sincerely
Central Enquiry Point
Information Centre
MHRA
Market Towers
London SW8 5NQ
Tel: +44 (0)207084 2000
FAX: +44 (0)207084 2353
source - http://groups.yahoo.com/group/uksurvivors/message/43157
Antidepressant suicide warning (on or about Aug 2000) - FOI request
Antidepressant suicide warning (on or about Aug 2000) - FOI request
http://groups.yahoo.com/group/uksurvivors/message/43156
Antidepressant suicide warning (on or about Aug 2000)
Freedom of Information
MHRA
Dear Sir/Madam
I refer to article "The missing warning on a drug for desperate people" published Thursday May 17, 2001
The Guardian re- published online here - http://www.guardian.co.UK/comment/story/0,3604,492305,00.HTML
I wish to draw to your attention the following paragraph(s)
"Occasionally thoughts of suicide or self harm may occur or may increase in the first few weeks of treatment with Seroxat, until the antidepressant effect becomes apparent. Tell your doctor immediately if you have any distressing thoughts or experiences."
Of which I note from the Guardian article -
"In August,(2000) the agency wrote asking the firm (GSK) to include the following straightforward words on the patient information leaflets stuffed into drug packets"
Whereas the article implies that the Agency wrote to GlaxoSmithKline maker of Seroxat my question under the terms of the Freedom of Information Act is -
Please provide a complete list of all makers of antidepressant drugs who received same or similar requests to add the following (or similar) wording to patient information leaflets "Occasionally thoughts of suicide or self harm may occur or may increase in the first few weeks of treatment with (insert name of drug) , until the antidepressant effect becomes apparent. Tell your doctor immediately if you have any distressing thoughts or experiences."
Please supply a copy of correspondence with/from said drug makers on the above matter.
Regards
J Bryce
XXXXX XXXXX
XXXX XXXXXX
XXXXX XXXX
XXXXX XXXX
N Ireland
http://groups.yahoo.com/group/uksurvivors/message/43156
Antidepressant suicide warning (on or about Aug 2000)
Freedom of Information
MHRA
Dear Sir/Madam
I refer to article "The missing warning on a drug for desperate people" published Thursday May 17, 2001
The Guardian re- published online here - http://www.guardian.co.UK/comment/story/0,3604,492305,00.HTML
I wish to draw to your attention the following paragraph(s)
"Occasionally thoughts of suicide or self harm may occur or may increase in the first few weeks of treatment with Seroxat, until the antidepressant effect becomes apparent. Tell your doctor immediately if you have any distressing thoughts or experiences."
Of which I note from the Guardian article -
"In August,(2000) the agency wrote asking the firm (GSK) to include the following straightforward words on the patient information leaflets stuffed into drug packets"
Whereas the article implies that the Agency wrote to GlaxoSmithKline maker of Seroxat my question under the terms of the Freedom of Information Act is -
Please provide a complete list of all makers of antidepressant drugs who received same or similar requests to add the following (or similar) wording to patient information leaflets "Occasionally thoughts of suicide or self harm may occur or may increase in the first few weeks of treatment with (insert name of drug) , until the antidepressant effect becomes apparent. Tell your doctor immediately if you have any distressing thoughts or experiences."
Please supply a copy of correspondence with/from said drug makers on the above matter.
Regards
J Bryce
XXXXX XXXXX
XXXX XXXXXX
XXXXX XXXX
XXXXX XXXX
N Ireland
The missing warning on a drug for desperate people - The Guardian May 17, 2001
http://www.network54.com/Forum/281849/message/1236851077/The+missing+warning+on+a+drug+for+desperate+people+-+Thursday+May+17%2C+2001
The missing warning on a drug for desperate people
http://www.guardian.co.uk/comment/story/0,3604,492305,00.html
Users of an antidepressant are not yet being alerted to a possible suicide risk
Ed Harriman
Thursday May 17, 2001
The Guardian
It may seem hard to believe that a big drug company would drag its feet over an official request to provide depressed people with warnings that might save their lives. But that is what appears to be happening.
The government's watchdog, the medicines control agency, decided almost a year ago to ask drug companies including GlaxoSmithKline the world's biggest, to warn patients of a possible risk of suicide associated with Prozac-style drugs. Glaxo's Seroxat is one of the most prescribed.
In August, the agency wrote asking the firm to include the following straightforward words on the patient information leaflets stuffed into drug packets:
"Occasionally thoughts of suicide or self harm may occur or may increase in the first few weeks of treatment with Seroxat, until the antidepressant effect becomes apparent. Tell your doctor immediately if you have any distressing thoughts or experiences."
Dr Keith Jones, director of the agency, said at the time: "The committee on the safety of medicines ... considered it was important that patients and the families of patients were made aware of a possible risk of an increase in suicidal behaviour." He added: "We are taking this issue very seriously."
However, patients prescribed GlaxoSmithKline's wonder drug will today look in vain for this warning. It seems the firm does not like the wording.
A director, Ian Hudson, was asked about this last December during US legal proceedings by lawyer Andy Vickery: (The drug is called Paxil in the US):
Vickery: "Incidentally, is SmithKline going to implement the new suicide warning that the medicines control agency in the UK recommended back in August of this year?"
Hudson: "Could you refer to ... tell me exactly what the warning is?"
Vickery: "The warning concerning suicide, suicide and Paxil. Have you seen it?"
Hudson: "Well SmithKline Beecham and the MCA have been in discussion in relation to ... including some wording within the UK data sheet. Exactly what the final wording will be, I don't know, I haven't seen it. I would have to consult my colleagues on that..."
Vickery: "But is SmithKline Beecham going to implement a wording change with respect to the issue of suicide on the Paxil label some time in the near future?"
Hudson: "We've certainly been in discussions with the MCA about that. I'm not sure whether that's finally resolved and when that's going to happen..."
(Shortly afterwards, Hudson left Glaxo and joined the medicines control agency in a senior position, although it is not suggested he personally handled this issue thereafter.)
Glaxo's public relations staff say their own, different wording was proposed to the agency in March and is now lying on the table. But they say it is "confidential".
So, to date, depressed patients continue to go without any warning at all.
Behind this bewildering and somewhat unsavoury delay, lie bigger issues. There is looming litigation, and large sums may be at stake for manufacturers of what has been hailed for years as a miracle drug.
Seroxat is an SSRI - a selective serotonin reuptake inhibitor - an antidepressant that works by changing the chemistry in the brain. SSRIs are being marketed for an ever-widening range of complaints, including premenstrual tension.
The chemical is GlaxoSmithKline's biggest selling drug, raising some £1.5bn last year, nearly £100m in the UK. Only Eli Lilly's Prozac, of all the SSRI's, outsells it. Many depression victims say it has helped them greatly.
But Seroxat has had special problems almost from the day it was licensed some 10 years ago. In 1993, the committee on safety of medicines - which advises the MCA - warned doctors that in light of "symptoms occurring on withdrawal ... including dizziness, sweating, nausea, insomnia, tremor and confusion ... [it] should not normally be discontinued abruptly."
Since then more adverse re action reports have been filed about Seroxat for problems associated with withdrawal symptoms than for all the other antidepressants, including Prozac, combined.
Suicide risk is another matter where GlaxoSmithKline faces challenges. This Monday, the firm goes on trial in Wyoming sued by the survivors after Donald Schell ran amok, shot family members and turned the gun on himself, two days after he was prescribed the drug in 1998. The family and Vickery, their no-nonsense Texas lawyer, hope to convince a jury that the drug triggered Mr Schell to go berserk. The firm deny this.
"What I intend to prove is that SmithKline knew about this potential risk for violence and suicide," says Vickery. It was he who recorded the deposition from Dr Hudson, then SmithKline's vice-president for clinical safety based in Harlow, Essex.
One of the big selling points of all SSRIs has been that they are less risky than older antidepressants, so-called tricyclic drugs. Promotion literature states boldly that Seroxat is "safe-in-overdose": if a patient swallows a bottle that in itself is unlikely to kill them.
But this is no longer the whole story, due to a crucial new study. Before Christmas an article appeared in the British Journal of Psychiatry by Dr Stuart Donovan and colleagues. It's their report of 2,776 patients taking SSRIs who turned up at Derbyshire Royal Infirmary over two years. They found that if you look for a statistically significant relationship between taking SSRIs and suicide by overdosing on them, you won't find much.
But they did find a relationship between taking SSRIs and all forms of deliberate self-harm - including overdose, attempted overdose, hanging, gassing, laceration, deliberate road traffic accidents, head banging, swallowing non-medicines - much higher for SSRIs than for the older tricyclics. (This applies whether the cause is SSRIs themselves or merely the delay in their effect.)
The relationship is so strong, Dr Donovan says, that he firmly believes promotional material for SSRIs including Seroxat should be changed immediately so doctors no longer prescribe them to potentially suicidal patients thinking, mistakenly, that by doing so they are protecting their lives.
Dr Donovan sent the manuscript to SmithKline Beecham (who partly financed the study with Eli Lilly) before it was published asking for comments. They never replied.
This history of controversy is hardly calculated to make depressed patients on Seroxat feel more comfortable. If they're worried - and indeed, as the warning with their pills would have told them had it been included by now - they should see their doctors for advice.
Ed Harriman is an investigative film-maker
"EdHarriman@..."'> color=#003366>EdHarriman@...
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The missing warning on a drug for desperate people
http://www.guardian.co.uk/comment/story/0,3604,492305,00.html
Users of an antidepressant are not yet being alerted to a possible suicide risk
Ed Harriman
Thursday May 17, 2001
The Guardian
It may seem hard to believe that a big drug company would drag its feet over an official request to provide depressed people with warnings that might save their lives. But that is what appears to be happening.
The government's watchdog, the medicines control agency, decided almost a year ago to ask drug companies including GlaxoSmithKline the world's biggest, to warn patients of a possible risk of suicide associated with Prozac-style drugs. Glaxo's Seroxat is one of the most prescribed.
In August, the agency wrote asking the firm to include the following straightforward words on the patient information leaflets stuffed into drug packets:
"Occasionally thoughts of suicide or self harm may occur or may increase in the first few weeks of treatment with Seroxat, until the antidepressant effect becomes apparent. Tell your doctor immediately if you have any distressing thoughts or experiences."
Dr Keith Jones, director of the agency, said at the time: "The committee on the safety of medicines ... considered it was important that patients and the families of patients were made aware of a possible risk of an increase in suicidal behaviour." He added: "We are taking this issue very seriously."
However, patients prescribed GlaxoSmithKline's wonder drug will today look in vain for this warning. It seems the firm does not like the wording.
A director, Ian Hudson, was asked about this last December during US legal proceedings by lawyer Andy Vickery: (The drug is called Paxil in the US):
Vickery: "Incidentally, is SmithKline going to implement the new suicide warning that the medicines control agency in the UK recommended back in August of this year?"
Hudson: "Could you refer to ... tell me exactly what the warning is?"
Vickery: "The warning concerning suicide, suicide and Paxil. Have you seen it?"
Hudson: "Well SmithKline Beecham and the MCA have been in discussion in relation to ... including some wording within the UK data sheet. Exactly what the final wording will be, I don't know, I haven't seen it. I would have to consult my colleagues on that..."
Vickery: "But is SmithKline Beecham going to implement a wording change with respect to the issue of suicide on the Paxil label some time in the near future?"
Hudson: "We've certainly been in discussions with the MCA about that. I'm not sure whether that's finally resolved and when that's going to happen..."
(Shortly afterwards, Hudson left Glaxo and joined the medicines control agency in a senior position, although it is not suggested he personally handled this issue thereafter.)
Glaxo's public relations staff say their own, different wording was proposed to the agency in March and is now lying on the table. But they say it is "confidential".
So, to date, depressed patients continue to go without any warning at all.
Behind this bewildering and somewhat unsavoury delay, lie bigger issues. There is looming litigation, and large sums may be at stake for manufacturers of what has been hailed for years as a miracle drug.
Seroxat is an SSRI - a selective serotonin reuptake inhibitor - an antidepressant that works by changing the chemistry in the brain. SSRIs are being marketed for an ever-widening range of complaints, including premenstrual tension.
The chemical is GlaxoSmithKline's biggest selling drug, raising some £1.5bn last year, nearly £100m in the UK. Only Eli Lilly's Prozac, of all the SSRI's, outsells it. Many depression victims say it has helped them greatly.
But Seroxat has had special problems almost from the day it was licensed some 10 years ago. In 1993, the committee on safety of medicines - which advises the MCA - warned doctors that in light of "symptoms occurring on withdrawal ... including dizziness, sweating, nausea, insomnia, tremor and confusion ... [it] should not normally be discontinued abruptly."
Since then more adverse re action reports have been filed about Seroxat for problems associated with withdrawal symptoms than for all the other antidepressants, including Prozac, combined.
Suicide risk is another matter where GlaxoSmithKline faces challenges. This Monday, the firm goes on trial in Wyoming sued by the survivors after Donald Schell ran amok, shot family members and turned the gun on himself, two days after he was prescribed the drug in 1998. The family and Vickery, their no-nonsense Texas lawyer, hope to convince a jury that the drug triggered Mr Schell to go berserk. The firm deny this.
"What I intend to prove is that SmithKline knew about this potential risk for violence and suicide," says Vickery. It was he who recorded the deposition from Dr Hudson, then SmithKline's vice-president for clinical safety based in Harlow, Essex.
One of the big selling points of all SSRIs has been that they are less risky than older antidepressants, so-called tricyclic drugs. Promotion literature states boldly that Seroxat is "safe-in-overdose": if a patient swallows a bottle that in itself is unlikely to kill them.
But this is no longer the whole story, due to a crucial new study. Before Christmas an article appeared in the British Journal of Psychiatry by Dr Stuart Donovan and colleagues. It's their report of 2,776 patients taking SSRIs who turned up at Derbyshire Royal Infirmary over two years. They found that if you look for a statistically significant relationship between taking SSRIs and suicide by overdosing on them, you won't find much.
But they did find a relationship between taking SSRIs and all forms of deliberate self-harm - including overdose, attempted overdose, hanging, gassing, laceration, deliberate road traffic accidents, head banging, swallowing non-medicines - much higher for SSRIs than for the older tricyclics. (This applies whether the cause is SSRIs themselves or merely the delay in their effect.)
The relationship is so strong, Dr Donovan says, that he firmly believes promotional material for SSRIs including Seroxat should be changed immediately so doctors no longer prescribe them to potentially suicidal patients thinking, mistakenly, that by doing so they are protecting their lives.
Dr Donovan sent the manuscript to SmithKline Beecham (who partly financed the study with Eli Lilly) before it was published asking for comments. They never replied.
This history of controversy is hardly calculated to make depressed patients on Seroxat feel more comfortable. If they're worried - and indeed, as the warning with their pills would have told them had it been included by now - they should see their doctors for advice.
Ed Harriman is an investigative film-maker
"EdHarriman@..."'> color=#003366>EdHarriman@...
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