NEWS - it's a "potent and irreversible inactivator of CYP2D6 (cytochrome P450 2D6), a key liver enzyme" IRREVERSIBLE

Paroxetine


has been shown to be an effective treatment for VMS. However, it is a potent and


irreversible inactivator of CYP2D6 (cytochrome P450 2D6), a key liver enzyme


responsible for the metabolism of many commonly-prescribed drugs.

http://www.reuters.com/article/pressRelease/idUS93196+14-Sep-2009+BW20090914